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Complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex

Cadherin is a cell adhesion molecule widely expressed in the nervous system. Previously, we analyzed the expression of nine classic cadherins (Cdh4, Cdh6, Cdh7, Cdh8, Cdh9, Cdh10, Cdh11, Cdh12, and Cdh20) and T‐cadherin (Cdh13) in the developing postnatal common marmoset (Callithrix jacchus) brain,...

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Autores principales: Matsunaga, Eiji, Nambu, Sanae, Oka, Mariko, Iriki, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744772/
https://www.ncbi.nlm.nih.gov/pubmed/26081465
http://dx.doi.org/10.1111/dgd.12228
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author Matsunaga, Eiji
Nambu, Sanae
Oka, Mariko
Iriki, Atsushi
author_facet Matsunaga, Eiji
Nambu, Sanae
Oka, Mariko
Iriki, Atsushi
author_sort Matsunaga, Eiji
collection PubMed
description Cadherin is a cell adhesion molecule widely expressed in the nervous system. Previously, we analyzed the expression of nine classic cadherins (Cdh4, Cdh6, Cdh7, Cdh8, Cdh9, Cdh10, Cdh11, Cdh12, and Cdh20) and T‐cadherin (Cdh13) in the developing postnatal common marmoset (Callithrix jacchus) brain, and found differential expressions between mice and marmosets. In this study, to explore primate‐specific cadherin expression at the embryonic stage, we extensively analyzed the expression of these cadherins in the developing embryonic marmoset brain. Each cadherin showed differential spatial and temporal expression and exhibited temporally complicated expression. Furthermore, the expression of some cadherins differed from that in rodent brains, even at the embryonic stage. These results suggest the possibility that the differential expressions of diverse cadherins are involved in primate specific cortical development, from the prenatal to postnatal period.
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spelling pubmed-47447722016-02-18 Complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex Matsunaga, Eiji Nambu, Sanae Oka, Mariko Iriki, Atsushi Dev Growth Differ Original Articles Cadherin is a cell adhesion molecule widely expressed in the nervous system. Previously, we analyzed the expression of nine classic cadherins (Cdh4, Cdh6, Cdh7, Cdh8, Cdh9, Cdh10, Cdh11, Cdh12, and Cdh20) and T‐cadherin (Cdh13) in the developing postnatal common marmoset (Callithrix jacchus) brain, and found differential expressions between mice and marmosets. In this study, to explore primate‐specific cadherin expression at the embryonic stage, we extensively analyzed the expression of these cadherins in the developing embryonic marmoset brain. Each cadherin showed differential spatial and temporal expression and exhibited temporally complicated expression. Furthermore, the expression of some cadherins differed from that in rodent brains, even at the embryonic stage. These results suggest the possibility that the differential expressions of diverse cadherins are involved in primate specific cortical development, from the prenatal to postnatal period. John Wiley and Sons Inc. 2015-06-17 2015-08 /pmc/articles/PMC4744772/ /pubmed/26081465 http://dx.doi.org/10.1111/dgd.12228 Text en © 2015 The Authors Development, Growth & Differentiation published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Society of Developmental Biologists. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Matsunaga, Eiji
Nambu, Sanae
Oka, Mariko
Iriki, Atsushi
Complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex
title Complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex
title_full Complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex
title_fullStr Complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex
title_full_unstemmed Complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex
title_short Complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex
title_sort complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744772/
https://www.ncbi.nlm.nih.gov/pubmed/26081465
http://dx.doi.org/10.1111/dgd.12228
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