Cargando…
Molecular characterization of HCV in a Swedish county over 8 years (2002–2009) reveals distinct transmission patterns
BACKGROUND: Hepatitis C virus (HCV) is a major public health concern and data on its molecular epidemiology in Sweden is scarce. We carried out an 8-year population-based study of newly diagnosed HCV cases in one of Sweden's centrally situated counties, Södermanland (D-county). The aim was to c...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Co-Action Publishing
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744866/ https://www.ncbi.nlm.nih.gov/pubmed/26854010 http://dx.doi.org/10.3402/iee.v6.30670 |
_version_ | 1782414540218040320 |
---|---|
author | Ederth, Josefine Jern, Camilla Norder, Helené Magnius, Lars Alm, Erik Rognsvåg, Björg Kleverman Sundin, Carl-Gustaf Brytting, Mia Esbjörnsson, Joakim Mild, Mattias |
author_facet | Ederth, Josefine Jern, Camilla Norder, Helené Magnius, Lars Alm, Erik Rognsvåg, Björg Kleverman Sundin, Carl-Gustaf Brytting, Mia Esbjörnsson, Joakim Mild, Mattias |
author_sort | Ederth, Josefine |
collection | PubMed |
description | BACKGROUND: Hepatitis C virus (HCV) is a major public health concern and data on its molecular epidemiology in Sweden is scarce. We carried out an 8-year population-based study of newly diagnosed HCV cases in one of Sweden's centrally situated counties, Södermanland (D-county). The aim was to characterize the HCV strains circulating, analyze their genetic relatedness to detect networks, and in combination with demographic data learn more about transmission. METHODS: Molecular analyses of serum samples from 91% (N=557) of all newly notified cases in D-county, 2002–2009, were performed. Phylogenetic analysis (NS5B gene, 300 bp) was linked to demographic data from the national surveillance database, SmiNet, to characterize D-county transmission clusters. The linear-by-linear association test (LBL) was used to analyze trends over time. RESULTS: The most prevalent subtypes were 1a (38%) and 3a (34%). Subtype 1a was most prevalent among cases transmitted via sexual contact, via contaminated blood, or blood products, while subtype 3a was most prevalent among people who inject drugs (PWIDs). Phylogenetic analysis revealed that the subtype 3a sequences formed more and larger transmission clusters (50% of the sequences clustered), while the 1a sequences formed smaller clusters (19% of the sequences clustered), possibly suggesting different epidemics. CONCLUSION: We found different transmission patterns in D-county which may, from a public health perspective, have implications for how to control virus infections by targeted interventions. |
format | Online Article Text |
id | pubmed-4744866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Co-Action Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-47448662016-03-01 Molecular characterization of HCV in a Swedish county over 8 years (2002–2009) reveals distinct transmission patterns Ederth, Josefine Jern, Camilla Norder, Helené Magnius, Lars Alm, Erik Rognsvåg, Björg Kleverman Sundin, Carl-Gustaf Brytting, Mia Esbjörnsson, Joakim Mild, Mattias Infect Ecol Epidemiol Original Research Article BACKGROUND: Hepatitis C virus (HCV) is a major public health concern and data on its molecular epidemiology in Sweden is scarce. We carried out an 8-year population-based study of newly diagnosed HCV cases in one of Sweden's centrally situated counties, Södermanland (D-county). The aim was to characterize the HCV strains circulating, analyze their genetic relatedness to detect networks, and in combination with demographic data learn more about transmission. METHODS: Molecular analyses of serum samples from 91% (N=557) of all newly notified cases in D-county, 2002–2009, were performed. Phylogenetic analysis (NS5B gene, 300 bp) was linked to demographic data from the national surveillance database, SmiNet, to characterize D-county transmission clusters. The linear-by-linear association test (LBL) was used to analyze trends over time. RESULTS: The most prevalent subtypes were 1a (38%) and 3a (34%). Subtype 1a was most prevalent among cases transmitted via sexual contact, via contaminated blood, or blood products, while subtype 3a was most prevalent among people who inject drugs (PWIDs). Phylogenetic analysis revealed that the subtype 3a sequences formed more and larger transmission clusters (50% of the sequences clustered), while the 1a sequences formed smaller clusters (19% of the sequences clustered), possibly suggesting different epidemics. CONCLUSION: We found different transmission patterns in D-county which may, from a public health perspective, have implications for how to control virus infections by targeted interventions. Co-Action Publishing 2016-02-05 /pmc/articles/PMC4744866/ /pubmed/26854010 http://dx.doi.org/10.3402/iee.v6.30670 Text en © 2016 Josefine Ederth et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Article Ederth, Josefine Jern, Camilla Norder, Helené Magnius, Lars Alm, Erik Rognsvåg, Björg Kleverman Sundin, Carl-Gustaf Brytting, Mia Esbjörnsson, Joakim Mild, Mattias Molecular characterization of HCV in a Swedish county over 8 years (2002–2009) reveals distinct transmission patterns |
title | Molecular characterization of HCV in a Swedish county over 8 years (2002–2009) reveals distinct transmission patterns |
title_full | Molecular characterization of HCV in a Swedish county over 8 years (2002–2009) reveals distinct transmission patterns |
title_fullStr | Molecular characterization of HCV in a Swedish county over 8 years (2002–2009) reveals distinct transmission patterns |
title_full_unstemmed | Molecular characterization of HCV in a Swedish county over 8 years (2002–2009) reveals distinct transmission patterns |
title_short | Molecular characterization of HCV in a Swedish county over 8 years (2002–2009) reveals distinct transmission patterns |
title_sort | molecular characterization of hcv in a swedish county over 8 years (2002–2009) reveals distinct transmission patterns |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744866/ https://www.ncbi.nlm.nih.gov/pubmed/26854010 http://dx.doi.org/10.3402/iee.v6.30670 |
work_keys_str_mv | AT ederthjosefine molecularcharacterizationofhcvinaswedishcountyover8years20022009revealsdistincttransmissionpatterns AT jerncamilla molecularcharacterizationofhcvinaswedishcountyover8years20022009revealsdistincttransmissionpatterns AT norderhelene molecularcharacterizationofhcvinaswedishcountyover8years20022009revealsdistincttransmissionpatterns AT magniuslars molecularcharacterizationofhcvinaswedishcountyover8years20022009revealsdistincttransmissionpatterns AT almerik molecularcharacterizationofhcvinaswedishcountyover8years20022009revealsdistincttransmissionpatterns AT rognsvagbjorgkleverman molecularcharacterizationofhcvinaswedishcountyover8years20022009revealsdistincttransmissionpatterns AT sundincarlgustaf molecularcharacterizationofhcvinaswedishcountyover8years20022009revealsdistincttransmissionpatterns AT bryttingmia molecularcharacterizationofhcvinaswedishcountyover8years20022009revealsdistincttransmissionpatterns AT esbjornssonjoakim molecularcharacterizationofhcvinaswedishcountyover8years20022009revealsdistincttransmissionpatterns AT mildmattias molecularcharacterizationofhcvinaswedishcountyover8years20022009revealsdistincttransmissionpatterns |