The Synthesis of Quinolone Natural Products from Pseudonocardia sp.

The synthesis of four quinolone natural products from the actinomycete Pseudonocardia sp. is reported. The key step involved a sp(2)–sp(3) Suzuki–Miyaura reaction between a common boronic ester lateral chain and various functionalised quinolone cores. The quinolones slowed growth of E. coli and S. a...

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Detalles Bibliográficos
Autores principales: Salvaggio, Flavia, Hodgkinson, James T., Carro, Laura, Geddis, Stephen M., Galloway, Warren R. J. D., Welch, Martin, Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744947/
http://dx.doi.org/10.1002/ejoc.201501400
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author Salvaggio, Flavia
Hodgkinson, James T.
Carro, Laura
Geddis, Stephen M.
Galloway, Warren R. J. D.
Welch, Martin
Spring, David R.
author_facet Salvaggio, Flavia
Hodgkinson, James T.
Carro, Laura
Geddis, Stephen M.
Galloway, Warren R. J. D.
Welch, Martin
Spring, David R.
author_sort Salvaggio, Flavia
collection PubMed
description The synthesis of four quinolone natural products from the actinomycete Pseudonocardia sp. is reported. The key step involved a sp(2)–sp(3) Suzuki–Miyaura reaction between a common boronic ester lateral chain and various functionalised quinolone cores. The quinolones slowed growth of E. coli and S. aureus by inducing extended lag phases.
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spelling pubmed-47449472016-02-25 The Synthesis of Quinolone Natural Products from Pseudonocardia sp. Salvaggio, Flavia Hodgkinson, James T. Carro, Laura Geddis, Stephen M. Galloway, Warren R. J. D. Welch, Martin Spring, David R. European J Org Chem Communications The synthesis of four quinolone natural products from the actinomycete Pseudonocardia sp. is reported. The key step involved a sp(2)–sp(3) Suzuki–Miyaura reaction between a common boronic ester lateral chain and various functionalised quinolone cores. The quinolones slowed growth of E. coli and S. aureus by inducing extended lag phases. WILEY‐VCH Verlag 2015-12-21 2016-01 /pmc/articles/PMC4744947/ http://dx.doi.org/10.1002/ejoc.201501400 Text en © 2016 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Open access.
spellingShingle Communications
Salvaggio, Flavia
Hodgkinson, James T.
Carro, Laura
Geddis, Stephen M.
Galloway, Warren R. J. D.
Welch, Martin
Spring, David R.
The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
title The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
title_full The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
title_fullStr The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
title_full_unstemmed The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
title_short The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
title_sort synthesis of quinolone natural products from pseudonocardia sp.
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744947/
http://dx.doi.org/10.1002/ejoc.201501400
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