Brain zinc chelation by diethyldithiocarbamate increased the behavioral and mitochondrial damages in zebrafish subjected to hypoxia

The increase in brain levels of chelatable zinc (Zn) in dysfunctions involving oxygen deprivation has stimulated the treatment with Zn chelators, such as diethyldithiocarbamate (DEDTC). However, DEDTC is a redox-active compound and it should be better evaluated during hypoxia. We use the hypoxia mod...

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Detalles Bibliográficos
Autores principales: Braga, Marcos M., Silva, Emerson S., Moraes, Tarsila B., Schirmbeck, Gabriel Henrique, Rico, Eduardo P., Pinto, Charles B., Rosemberg, Denis B., Dutra-Filho, Carlos S., Dias, Renato D., Oliveira, Diogo L., T. Rocha, João Batista, Souza, Diogo O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745017/
https://www.ncbi.nlm.nih.gov/pubmed/26854133
http://dx.doi.org/10.1038/srep20279

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