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Generation of TALE nickase-mediated gene-targeted cows expressing human serum albumin in mammary glands

Targeting exogenous genes at milk protein loci via gene-targeting technology is an ideal strategy for producing large quantities of pharmaceutical proteins. Transcription- activator-like effector (TALE) nucleases (TALENs) are an efficient genome-editing tool. However, the off-target effects may lead...

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Detalles Bibliográficos
Autores principales:	Luo, Yan, Wang, Yongsheng, Liu, Jun, Cui, Chenchen, Wu, Yongyan, Lan, Hui, Chen, Qi, Liu, Xu, Quan, Fusheng, Guo, Zekun, Zhang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745098/ https://www.ncbi.nlm.nih.gov/pubmed/26853907 http://dx.doi.org/10.1038/srep20657

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