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Venous thromboembolism and persistent pulmonary hypertension in cancer patients: a cross-sectional study

BACKGROUND: Cancer patients are at increased risk for venous thromboembolism (VTE). OBJECTIVE: This monocenter cross-sectional study prospectively assessed the association between a history of ≥1 VTE episode and the presence of pulmonary hypertension (PH) among cancer patients presenting with pulmon...

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Autores principales: Wieshammer, Siegfried, Dreyhaupt, Jens, Müller, Dirk, Momm, Felix, Jakob, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745153/
https://www.ncbi.nlm.nih.gov/pubmed/26858584
http://dx.doi.org/10.1186/s12959-016-0077-1
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author Wieshammer, Siegfried
Dreyhaupt, Jens
Müller, Dirk
Momm, Felix
Jakob, Andreas
author_facet Wieshammer, Siegfried
Dreyhaupt, Jens
Müller, Dirk
Momm, Felix
Jakob, Andreas
author_sort Wieshammer, Siegfried
collection PubMed
description BACKGROUND: Cancer patients are at increased risk for venous thromboembolism (VTE). OBJECTIVE: This monocenter cross-sectional study prospectively assessed the association between a history of ≥1 VTE episode and the presence of pulmonary hypertension (PH) among cancer patients presenting with pulmonary or cardiac symptoms. METHODS: A consecutive series of 583 patients underwent a diagnostic work-up for heart and lung disease. PH was diagnosed if a patient’s peak systolic pressure gradient across the tricuspid valve was ≥35 mmHg, as measured by echocardiography. Using multiple logistic regression analysis, the association between VTE and PH was assessed, following adjustments for age, the presence of severe airway obstruction, atrial fibrillation and left heart diseases. RESULTS: The prevalence values for PH (n = 90) and a history of VTE (n = 72) were 15.4 and 12.3 %, respectively. The median time interval between the first VTE episode and referral was 43 months. The odds of PH was higher in the subgroup with VTE (19/72; 26.4 %) than that without VTE (71/511; 13.9 %) in the unadjusted analysis [odds ratio (OR) 2.2, 95 % confidence interval (CI) 1.2, 4.0] and the adjusted model [OR 2.4, 95 % CI 1.2, 4.5]. The risk of PH did not depend on the time interval between VTE and referral. Older age and the presence of severe airway obstruction, atrial fibrillation, and left heart diseases were also associated with an increased odds of PH. CONCLUSION: In cancer patients presenting with cardiac or pulmonary symptoms, previous VTE is associated with an increased risk of persistent PH.
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spelling pubmed-47451532016-02-09 Venous thromboembolism and persistent pulmonary hypertension in cancer patients: a cross-sectional study Wieshammer, Siegfried Dreyhaupt, Jens Müller, Dirk Momm, Felix Jakob, Andreas Thromb J Original Clinical Investigation BACKGROUND: Cancer patients are at increased risk for venous thromboembolism (VTE). OBJECTIVE: This monocenter cross-sectional study prospectively assessed the association between a history of ≥1 VTE episode and the presence of pulmonary hypertension (PH) among cancer patients presenting with pulmonary or cardiac symptoms. METHODS: A consecutive series of 583 patients underwent a diagnostic work-up for heart and lung disease. PH was diagnosed if a patient’s peak systolic pressure gradient across the tricuspid valve was ≥35 mmHg, as measured by echocardiography. Using multiple logistic regression analysis, the association between VTE and PH was assessed, following adjustments for age, the presence of severe airway obstruction, atrial fibrillation and left heart diseases. RESULTS: The prevalence values for PH (n = 90) and a history of VTE (n = 72) were 15.4 and 12.3 %, respectively. The median time interval between the first VTE episode and referral was 43 months. The odds of PH was higher in the subgroup with VTE (19/72; 26.4 %) than that without VTE (71/511; 13.9 %) in the unadjusted analysis [odds ratio (OR) 2.2, 95 % confidence interval (CI) 1.2, 4.0] and the adjusted model [OR 2.4, 95 % CI 1.2, 4.5]. The risk of PH did not depend on the time interval between VTE and referral. Older age and the presence of severe airway obstruction, atrial fibrillation, and left heart diseases were also associated with an increased odds of PH. CONCLUSION: In cancer patients presenting with cardiac or pulmonary symptoms, previous VTE is associated with an increased risk of persistent PH. BioMed Central 2016-02-08 /pmc/articles/PMC4745153/ /pubmed/26858584 http://dx.doi.org/10.1186/s12959-016-0077-1 Text en © Wieshammer et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Clinical Investigation
Wieshammer, Siegfried
Dreyhaupt, Jens
Müller, Dirk
Momm, Felix
Jakob, Andreas
Venous thromboembolism and persistent pulmonary hypertension in cancer patients: a cross-sectional study
title Venous thromboembolism and persistent pulmonary hypertension in cancer patients: a cross-sectional study
title_full Venous thromboembolism and persistent pulmonary hypertension in cancer patients: a cross-sectional study
title_fullStr Venous thromboembolism and persistent pulmonary hypertension in cancer patients: a cross-sectional study
title_full_unstemmed Venous thromboembolism and persistent pulmonary hypertension in cancer patients: a cross-sectional study
title_short Venous thromboembolism and persistent pulmonary hypertension in cancer patients: a cross-sectional study
title_sort venous thromboembolism and persistent pulmonary hypertension in cancer patients: a cross-sectional study
topic Original Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745153/
https://www.ncbi.nlm.nih.gov/pubmed/26858584
http://dx.doi.org/10.1186/s12959-016-0077-1
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