The antiviral compound BIT225 inhibits HIV-1 replication in myeloid dendritic cells

BACKGROUND: Previous studies with BIT225 (N-carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide) have demonstrated a unique antiviral activity that blocks the release of HIV-1 from monocyte-derived macrophages (MDM). Antagonising the ion channel formed by HIV-1 Vpu, BIT225 preferentially target...

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Detalles Bibliográficos
Autores principales: Khoury, Gabriela, Ewart, Gary, Luscombe, Carolyn, Miller, Michelle, Wilkinson, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745167/
https://www.ncbi.nlm.nih.gov/pubmed/26858771
http://dx.doi.org/10.1186/s12981-016-0093-z

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