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Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital

BACKGROUND: Endothelial keratoplasty (EK) is used increasingly for the management of cases with endothelial dysfunction. Long-term outcomes of the surgery are not widely reported in the literature. We report our experience of EK in Chinese eyes at a University teaching hospital. METHODS: Retrospecti...

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Autores principales: Young, Alvin L, Kwok, Rachel PW, Jhanji, Vishal, Cheng, Lulu L, Rao, Srinivas K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745171/
https://www.ncbi.nlm.nih.gov/pubmed/26858960
http://dx.doi.org/10.1186/s40662-014-0008-9
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author Young, Alvin L
Kwok, Rachel PW
Jhanji, Vishal
Cheng, Lulu L
Rao, Srinivas K
author_facet Young, Alvin L
Kwok, Rachel PW
Jhanji, Vishal
Cheng, Lulu L
Rao, Srinivas K
author_sort Young, Alvin L
collection PubMed
description BACKGROUND: Endothelial keratoplasty (EK) is used increasingly for the management of cases with endothelial dysfunction. Long-term outcomes of the surgery are not widely reported in the literature. We report our experience of EK in Chinese eyes at a University teaching hospital. METHODS: Retrospective analysis was performed for all cases of EK performed between 2005 and 2009. Data analyzed included indication for surgery, associated surgical procedures, complications, best-corrected visual acuity (BCVA) and overall graft survival. RESULTS: Overall, 22 eyes of 21 patients underwent EK (13 males, 8 females, mean age 71.8 ± 11.3 years). Pseudophakic bullous keratopathy was the leading indication for surgery (n = 12) followed by Fuchs’ endothelial dystrophy (n = 4), or both (n = 3). Other indications for surgery included failed penetrating keratoplasty (n = 2) and endothelial decompensation due to multiple surgeries (n = 1). Triple procedure was performed in 5 (22.7%) cases. Complications were noted in the form of postoperative interface hemorrhage (n = 2, 9%) and graft dislocation (n = 1, 4.5%). The mean postoperative endothelial cell density was 1069 ± 585.8 cells/mm(2). The mean postoperative pachymetry was 675.8 ± 108.5 μm. The mean preoperative and postoperative intraocular pressure was 11.3 ± 3.2 and 13.9 ± 4.5 mmHg respectively. At the last follow-up (mean, 47.4 ± 13.7 months), BCVA was ≥20/70 in 9 (40.9%) cases. Causes of poor BCVA included primary graft failure (n = 4), graft decompensation (n = 4), advanced glaucoma (n = 2) and irreversible graft rejection (n = 2). Graft remained clear in 12 (54.5%) cases at the last follow-up. Average graft survival was 19.7 ± 17.7 months (median 17.5 months). CONCLUSIONS: Nearly half of the EK grafts in our study survived over a period of five years. Graft failure, glaucoma and graft rejection were the main causes of poor graft survival.
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spelling pubmed-47451712016-02-09 Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital Young, Alvin L Kwok, Rachel PW Jhanji, Vishal Cheng, Lulu L Rao, Srinivas K Eye Vis (Lond) Research BACKGROUND: Endothelial keratoplasty (EK) is used increasingly for the management of cases with endothelial dysfunction. Long-term outcomes of the surgery are not widely reported in the literature. We report our experience of EK in Chinese eyes at a University teaching hospital. METHODS: Retrospective analysis was performed for all cases of EK performed between 2005 and 2009. Data analyzed included indication for surgery, associated surgical procedures, complications, best-corrected visual acuity (BCVA) and overall graft survival. RESULTS: Overall, 22 eyes of 21 patients underwent EK (13 males, 8 females, mean age 71.8 ± 11.3 years). Pseudophakic bullous keratopathy was the leading indication for surgery (n = 12) followed by Fuchs’ endothelial dystrophy (n = 4), or both (n = 3). Other indications for surgery included failed penetrating keratoplasty (n = 2) and endothelial decompensation due to multiple surgeries (n = 1). Triple procedure was performed in 5 (22.7%) cases. Complications were noted in the form of postoperative interface hemorrhage (n = 2, 9%) and graft dislocation (n = 1, 4.5%). The mean postoperative endothelial cell density was 1069 ± 585.8 cells/mm(2). The mean postoperative pachymetry was 675.8 ± 108.5 μm. The mean preoperative and postoperative intraocular pressure was 11.3 ± 3.2 and 13.9 ± 4.5 mmHg respectively. At the last follow-up (mean, 47.4 ± 13.7 months), BCVA was ≥20/70 in 9 (40.9%) cases. Causes of poor BCVA included primary graft failure (n = 4), graft decompensation (n = 4), advanced glaucoma (n = 2) and irreversible graft rejection (n = 2). Graft remained clear in 12 (54.5%) cases at the last follow-up. Average graft survival was 19.7 ± 17.7 months (median 17.5 months). CONCLUSIONS: Nearly half of the EK grafts in our study survived over a period of five years. Graft failure, glaucoma and graft rejection were the main causes of poor graft survival. BioMed Central 2014-12-01 /pmc/articles/PMC4745171/ /pubmed/26858960 http://dx.doi.org/10.1186/s40662-014-0008-9 Text en © Young et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Young, Alvin L
Kwok, Rachel PW
Jhanji, Vishal
Cheng, Lulu L
Rao, Srinivas K
Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital
title Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital
title_full Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital
title_fullStr Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital
title_full_unstemmed Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital
title_short Long-term outcomes of endothelial keratoplasty in Chinese eyes at a University Hospital
title_sort long-term outcomes of endothelial keratoplasty in chinese eyes at a university hospital
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745171/
https://www.ncbi.nlm.nih.gov/pubmed/26858960
http://dx.doi.org/10.1186/s40662-014-0008-9
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