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Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea

Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference,...

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Autores principales: Wang, Xiaoya, Yu, Qin, Yue, Hongmei, Zhang, Jiabin, Zeng, Shuang, Cui, Fenfen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745295/
https://www.ncbi.nlm.nih.gov/pubmed/26904688
http://dx.doi.org/10.1155/2016/9782031
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author Wang, Xiaoya
Yu, Qin
Yue, Hongmei
Zhang, Jiabin
Zeng, Shuang
Cui, Fenfen
author_facet Wang, Xiaoya
Yu, Qin
Yue, Hongmei
Zhang, Jiabin
Zeng, Shuang
Cui, Fenfen
author_sort Wang, Xiaoya
collection PubMed
description Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference, lipids, blood glucose and insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), anandamide (AEA), 1/2-arachidonoylglycerol (1/2-AG), and apnea-hypopnea index (AHI) were analyzed. Results. Fasting blood insulin (22.9 ± 7.8 mIU/L versus 18.5 ± 7.2 mIU/L, P < 0.05), HOMA-IR (2.9 ± 1.0 versus 2.4 ± 0.9, P < 0.01), AEA (3.2 ± 0.7 nmol/L versus 2.5 ± 0.6 nmol/L, P < 0.01), and 1/2-AG (40.8 ± 5.7 nmol/L versus 34.3 ± 7.7 nmol/L, P < 0.01) were higher in OSA group than those in control group. In OSA group, AEA, 1/2-AG, and HOMA-IR increase with the OSA severity. The correlation analysis showed significant positive correlation between HOMA-IR and AHI (r = 0.44, P < 0.01), AEA and AHI (r = 0.52, P < 0.01), AEA and HOMA-IR (r = 0.62, P < 0.01), and 1/2-AG and HOMA-IR (r = 0.33, P < 0.01). Further analysis showed that only AEA was significantly correlated with AHI and HOMA-IR after adjusting for confounding factors. Conclusions. The present study indicated that plasma endocannabinoids levels, especially AEA, were associated with IR and AHI in patients with OSA.
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spelling pubmed-47452952016-02-22 Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea Wang, Xiaoya Yu, Qin Yue, Hongmei Zhang, Jiabin Zeng, Shuang Cui, Fenfen Biomed Res Int Research Article Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference, lipids, blood glucose and insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), anandamide (AEA), 1/2-arachidonoylglycerol (1/2-AG), and apnea-hypopnea index (AHI) were analyzed. Results. Fasting blood insulin (22.9 ± 7.8 mIU/L versus 18.5 ± 7.2 mIU/L, P < 0.05), HOMA-IR (2.9 ± 1.0 versus 2.4 ± 0.9, P < 0.01), AEA (3.2 ± 0.7 nmol/L versus 2.5 ± 0.6 nmol/L, P < 0.01), and 1/2-AG (40.8 ± 5.7 nmol/L versus 34.3 ± 7.7 nmol/L, P < 0.01) were higher in OSA group than those in control group. In OSA group, AEA, 1/2-AG, and HOMA-IR increase with the OSA severity. The correlation analysis showed significant positive correlation between HOMA-IR and AHI (r = 0.44, P < 0.01), AEA and AHI (r = 0.52, P < 0.01), AEA and HOMA-IR (r = 0.62, P < 0.01), and 1/2-AG and HOMA-IR (r = 0.33, P < 0.01). Further analysis showed that only AEA was significantly correlated with AHI and HOMA-IR after adjusting for confounding factors. Conclusions. The present study indicated that plasma endocannabinoids levels, especially AEA, were associated with IR and AHI in patients with OSA. Hindawi Publishing Corporation 2016 2016-01-19 /pmc/articles/PMC4745295/ /pubmed/26904688 http://dx.doi.org/10.1155/2016/9782031 Text en Copyright © 2016 Xiaoya Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Xiaoya
Yu, Qin
Yue, Hongmei
Zhang, Jiabin
Zeng, Shuang
Cui, Fenfen
Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title_full Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title_fullStr Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title_full_unstemmed Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title_short Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title_sort circulating endocannabinoids and insulin resistance in patients with obstructive sleep apnea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745295/
https://www.ncbi.nlm.nih.gov/pubmed/26904688
http://dx.doi.org/10.1155/2016/9782031
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