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Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745295/ https://www.ncbi.nlm.nih.gov/pubmed/26904688 http://dx.doi.org/10.1155/2016/9782031 |
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author | Wang, Xiaoya Yu, Qin Yue, Hongmei Zhang, Jiabin Zeng, Shuang Cui, Fenfen |
author_facet | Wang, Xiaoya Yu, Qin Yue, Hongmei Zhang, Jiabin Zeng, Shuang Cui, Fenfen |
author_sort | Wang, Xiaoya |
collection | PubMed |
description | Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference, lipids, blood glucose and insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), anandamide (AEA), 1/2-arachidonoylglycerol (1/2-AG), and apnea-hypopnea index (AHI) were analyzed. Results. Fasting blood insulin (22.9 ± 7.8 mIU/L versus 18.5 ± 7.2 mIU/L, P < 0.05), HOMA-IR (2.9 ± 1.0 versus 2.4 ± 0.9, P < 0.01), AEA (3.2 ± 0.7 nmol/L versus 2.5 ± 0.6 nmol/L, P < 0.01), and 1/2-AG (40.8 ± 5.7 nmol/L versus 34.3 ± 7.7 nmol/L, P < 0.01) were higher in OSA group than those in control group. In OSA group, AEA, 1/2-AG, and HOMA-IR increase with the OSA severity. The correlation analysis showed significant positive correlation between HOMA-IR and AHI (r = 0.44, P < 0.01), AEA and AHI (r = 0.52, P < 0.01), AEA and HOMA-IR (r = 0.62, P < 0.01), and 1/2-AG and HOMA-IR (r = 0.33, P < 0.01). Further analysis showed that only AEA was significantly correlated with AHI and HOMA-IR after adjusting for confounding factors. Conclusions. The present study indicated that plasma endocannabinoids levels, especially AEA, were associated with IR and AHI in patients with OSA. |
format | Online Article Text |
id | pubmed-4745295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47452952016-02-22 Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea Wang, Xiaoya Yu, Qin Yue, Hongmei Zhang, Jiabin Zeng, Shuang Cui, Fenfen Biomed Res Int Research Article Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference, lipids, blood glucose and insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), anandamide (AEA), 1/2-arachidonoylglycerol (1/2-AG), and apnea-hypopnea index (AHI) were analyzed. Results. Fasting blood insulin (22.9 ± 7.8 mIU/L versus 18.5 ± 7.2 mIU/L, P < 0.05), HOMA-IR (2.9 ± 1.0 versus 2.4 ± 0.9, P < 0.01), AEA (3.2 ± 0.7 nmol/L versus 2.5 ± 0.6 nmol/L, P < 0.01), and 1/2-AG (40.8 ± 5.7 nmol/L versus 34.3 ± 7.7 nmol/L, P < 0.01) were higher in OSA group than those in control group. In OSA group, AEA, 1/2-AG, and HOMA-IR increase with the OSA severity. The correlation analysis showed significant positive correlation between HOMA-IR and AHI (r = 0.44, P < 0.01), AEA and AHI (r = 0.52, P < 0.01), AEA and HOMA-IR (r = 0.62, P < 0.01), and 1/2-AG and HOMA-IR (r = 0.33, P < 0.01). Further analysis showed that only AEA was significantly correlated with AHI and HOMA-IR after adjusting for confounding factors. Conclusions. The present study indicated that plasma endocannabinoids levels, especially AEA, were associated with IR and AHI in patients with OSA. Hindawi Publishing Corporation 2016 2016-01-19 /pmc/articles/PMC4745295/ /pubmed/26904688 http://dx.doi.org/10.1155/2016/9782031 Text en Copyright © 2016 Xiaoya Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Xiaoya Yu, Qin Yue, Hongmei Zhang, Jiabin Zeng, Shuang Cui, Fenfen Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title | Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title_full | Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title_fullStr | Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title_full_unstemmed | Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title_short | Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title_sort | circulating endocannabinoids and insulin resistance in patients with obstructive sleep apnea |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745295/ https://www.ncbi.nlm.nih.gov/pubmed/26904688 http://dx.doi.org/10.1155/2016/9782031 |
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