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Memory Deficit Recovery after Chronic Vanadium Exposure in Mice

Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system. This work was designed to assess memory deficits in mice chronically exposed to vanadium. A total of 132 male BALB/c mice (4 weeks old) were used for the experiment and were divided into th...

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Autores principales: Folarin, Oluwabusayo, Olopade, Funmilayo, Onwuka, Silas, Olopade, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745327/
https://www.ncbi.nlm.nih.gov/pubmed/26962395
http://dx.doi.org/10.1155/2016/4860582
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author Folarin, Oluwabusayo
Olopade, Funmilayo
Onwuka, Silas
Olopade, James
author_facet Folarin, Oluwabusayo
Olopade, Funmilayo
Onwuka, Silas
Olopade, James
author_sort Folarin, Oluwabusayo
collection PubMed
description Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system. This work was designed to assess memory deficits in mice chronically exposed to vanadium. A total of 132 male BALB/c mice (4 weeks old) were used for the experiment and were divided into three major groups of vanadium treated, matched controls, and animals exposed to vanadium for three months and thereafter vanadium was withdrawn. Animals were tested using Morris water maze and forelimb grip test at 3, 6, 9, and 12 months of age. The results showed that animals across the groups showed no difference in learning but had significant loss in memory abilities after 3 months of vanadium exposure and this trend continued in all vanadium-exposed groups relative to the controls. Animals exposed to vanadium for three months recovered significantly only 9 months after vanadium withdrawal. There was no significant difference in latency to fall in the forelimb grip test between vanadium-exposed groups and the controls in all age groups. In conclusion, we have shown that chronic administration of vanadium in mice leads to memory deficit which is reversible but only after a long period of vanadium withdrawal.
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spelling pubmed-47453272016-03-09 Memory Deficit Recovery after Chronic Vanadium Exposure in Mice Folarin, Oluwabusayo Olopade, Funmilayo Onwuka, Silas Olopade, James Oxid Med Cell Longev Research Article Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system. This work was designed to assess memory deficits in mice chronically exposed to vanadium. A total of 132 male BALB/c mice (4 weeks old) were used for the experiment and were divided into three major groups of vanadium treated, matched controls, and animals exposed to vanadium for three months and thereafter vanadium was withdrawn. Animals were tested using Morris water maze and forelimb grip test at 3, 6, 9, and 12 months of age. The results showed that animals across the groups showed no difference in learning but had significant loss in memory abilities after 3 months of vanadium exposure and this trend continued in all vanadium-exposed groups relative to the controls. Animals exposed to vanadium for three months recovered significantly only 9 months after vanadium withdrawal. There was no significant difference in latency to fall in the forelimb grip test between vanadium-exposed groups and the controls in all age groups. In conclusion, we have shown that chronic administration of vanadium in mice leads to memory deficit which is reversible but only after a long period of vanadium withdrawal. Hindawi Publishing Corporation 2016 2016-01-19 /pmc/articles/PMC4745327/ /pubmed/26962395 http://dx.doi.org/10.1155/2016/4860582 Text en Copyright © 2016 Oluwabusayo Folarin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Folarin, Oluwabusayo
Olopade, Funmilayo
Onwuka, Silas
Olopade, James
Memory Deficit Recovery after Chronic Vanadium Exposure in Mice
title Memory Deficit Recovery after Chronic Vanadium Exposure in Mice
title_full Memory Deficit Recovery after Chronic Vanadium Exposure in Mice
title_fullStr Memory Deficit Recovery after Chronic Vanadium Exposure in Mice
title_full_unstemmed Memory Deficit Recovery after Chronic Vanadium Exposure in Mice
title_short Memory Deficit Recovery after Chronic Vanadium Exposure in Mice
title_sort memory deficit recovery after chronic vanadium exposure in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745327/
https://www.ncbi.nlm.nih.gov/pubmed/26962395
http://dx.doi.org/10.1155/2016/4860582
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