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Memory Deficit Recovery after Chronic Vanadium Exposure in Mice
Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system. This work was designed to assess memory deficits in mice chronically exposed to vanadium. A total of 132 male BALB/c mice (4 weeks old) were used for the experiment and were divided into th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745327/ https://www.ncbi.nlm.nih.gov/pubmed/26962395 http://dx.doi.org/10.1155/2016/4860582 |
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author | Folarin, Oluwabusayo Olopade, Funmilayo Onwuka, Silas Olopade, James |
author_facet | Folarin, Oluwabusayo Olopade, Funmilayo Onwuka, Silas Olopade, James |
author_sort | Folarin, Oluwabusayo |
collection | PubMed |
description | Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system. This work was designed to assess memory deficits in mice chronically exposed to vanadium. A total of 132 male BALB/c mice (4 weeks old) were used for the experiment and were divided into three major groups of vanadium treated, matched controls, and animals exposed to vanadium for three months and thereafter vanadium was withdrawn. Animals were tested using Morris water maze and forelimb grip test at 3, 6, 9, and 12 months of age. The results showed that animals across the groups showed no difference in learning but had significant loss in memory abilities after 3 months of vanadium exposure and this trend continued in all vanadium-exposed groups relative to the controls. Animals exposed to vanadium for three months recovered significantly only 9 months after vanadium withdrawal. There was no significant difference in latency to fall in the forelimb grip test between vanadium-exposed groups and the controls in all age groups. In conclusion, we have shown that chronic administration of vanadium in mice leads to memory deficit which is reversible but only after a long period of vanadium withdrawal. |
format | Online Article Text |
id | pubmed-4745327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47453272016-03-09 Memory Deficit Recovery after Chronic Vanadium Exposure in Mice Folarin, Oluwabusayo Olopade, Funmilayo Onwuka, Silas Olopade, James Oxid Med Cell Longev Research Article Vanadium is a transitional metal with an ability to generate reactive oxygen species in the biological system. This work was designed to assess memory deficits in mice chronically exposed to vanadium. A total of 132 male BALB/c mice (4 weeks old) were used for the experiment and were divided into three major groups of vanadium treated, matched controls, and animals exposed to vanadium for three months and thereafter vanadium was withdrawn. Animals were tested using Morris water maze and forelimb grip test at 3, 6, 9, and 12 months of age. The results showed that animals across the groups showed no difference in learning but had significant loss in memory abilities after 3 months of vanadium exposure and this trend continued in all vanadium-exposed groups relative to the controls. Animals exposed to vanadium for three months recovered significantly only 9 months after vanadium withdrawal. There was no significant difference in latency to fall in the forelimb grip test between vanadium-exposed groups and the controls in all age groups. In conclusion, we have shown that chronic administration of vanadium in mice leads to memory deficit which is reversible but only after a long period of vanadium withdrawal. Hindawi Publishing Corporation 2016 2016-01-19 /pmc/articles/PMC4745327/ /pubmed/26962395 http://dx.doi.org/10.1155/2016/4860582 Text en Copyright © 2016 Oluwabusayo Folarin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Folarin, Oluwabusayo Olopade, Funmilayo Onwuka, Silas Olopade, James Memory Deficit Recovery after Chronic Vanadium Exposure in Mice |
title | Memory Deficit Recovery after Chronic Vanadium Exposure in Mice |
title_full | Memory Deficit Recovery after Chronic Vanadium Exposure in Mice |
title_fullStr | Memory Deficit Recovery after Chronic Vanadium Exposure in Mice |
title_full_unstemmed | Memory Deficit Recovery after Chronic Vanadium Exposure in Mice |
title_short | Memory Deficit Recovery after Chronic Vanadium Exposure in Mice |
title_sort | memory deficit recovery after chronic vanadium exposure in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745327/ https://www.ncbi.nlm.nih.gov/pubmed/26962395 http://dx.doi.org/10.1155/2016/4860582 |
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