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An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus

Purpose. To study the corneal nerve morphology and its importance in unilateral keratoconus. Materials and Methods. In this prospective cross-sectional study, 33 eyes of 33 patients with keratoconus in one eye (Group 3) were compared with the other normal eye of the same patients (Group 2) and 30 ey...

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Autores principales: Pahuja, Natasha Kishore, Shetty, Rohit, Nuijts, Rudy M. M. A., Agrawal, Aarti, Ghosh, Arkasubhra, Jayadev, Chaitra, Nagaraja, Harsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745354/
https://www.ncbi.nlm.nih.gov/pubmed/26904679
http://dx.doi.org/10.1155/2016/5067853
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author Pahuja, Natasha Kishore
Shetty, Rohit
Nuijts, Rudy M. M. A.
Agrawal, Aarti
Ghosh, Arkasubhra
Jayadev, Chaitra
Nagaraja, Harsha
author_facet Pahuja, Natasha Kishore
Shetty, Rohit
Nuijts, Rudy M. M. A.
Agrawal, Aarti
Ghosh, Arkasubhra
Jayadev, Chaitra
Nagaraja, Harsha
author_sort Pahuja, Natasha Kishore
collection PubMed
description Purpose. To study the corneal nerve morphology and its importance in unilateral keratoconus. Materials and Methods. In this prospective cross-sectional study, 33 eyes of 33 patients with keratoconus in one eye (Group 3) were compared with the other normal eye of the same patients (Group 2) and 30 eyes of healthy patients (Group 1). All patients underwent detailed ophthalmic examination followed by topography with Pentacam HR and in vivo confocal microscopy (IVCM). Five images obtained with IVCM were analyzed using an automated CCmetrics software version 1.0 for changes in subbasal plexus of nerves. Results. Intergroup comparison showed statistically significant reduction in corneal nerve fiber density (CNFD) and length (CNFL) in Group 3 as compared to Group 1 (p < 0.001 and p = 0.001, resp.) and Group 2 (p = 0.01 and p = 0.02, resp.). Though corneal nerve fiber length, diameter, area, width, corneal nerve branch density, and corneal total branch density were found to be higher in decentered cones, only the corneal nerve branch density (CNBD) was found to be statistically significant (p < 0.01) as compared to centered cones. Conclusion. Quantitative changes in the corneal nerve morphology can be used as an imaging marker for the early diagnosis of keratoconus before the onset of refractive or topography changes.
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spelling pubmed-47453542016-02-22 An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus Pahuja, Natasha Kishore Shetty, Rohit Nuijts, Rudy M. M. A. Agrawal, Aarti Ghosh, Arkasubhra Jayadev, Chaitra Nagaraja, Harsha Biomed Res Int Research Article Purpose. To study the corneal nerve morphology and its importance in unilateral keratoconus. Materials and Methods. In this prospective cross-sectional study, 33 eyes of 33 patients with keratoconus in one eye (Group 3) were compared with the other normal eye of the same patients (Group 2) and 30 eyes of healthy patients (Group 1). All patients underwent detailed ophthalmic examination followed by topography with Pentacam HR and in vivo confocal microscopy (IVCM). Five images obtained with IVCM were analyzed using an automated CCmetrics software version 1.0 for changes in subbasal plexus of nerves. Results. Intergroup comparison showed statistically significant reduction in corneal nerve fiber density (CNFD) and length (CNFL) in Group 3 as compared to Group 1 (p < 0.001 and p = 0.001, resp.) and Group 2 (p = 0.01 and p = 0.02, resp.). Though corneal nerve fiber length, diameter, area, width, corneal nerve branch density, and corneal total branch density were found to be higher in decentered cones, only the corneal nerve branch density (CNBD) was found to be statistically significant (p < 0.01) as compared to centered cones. Conclusion. Quantitative changes in the corneal nerve morphology can be used as an imaging marker for the early diagnosis of keratoconus before the onset of refractive or topography changes. Hindawi Publishing Corporation 2016 2016-01-21 /pmc/articles/PMC4745354/ /pubmed/26904679 http://dx.doi.org/10.1155/2016/5067853 Text en Copyright © 2016 Natasha Kishore Pahuja et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pahuja, Natasha Kishore
Shetty, Rohit
Nuijts, Rudy M. M. A.
Agrawal, Aarti
Ghosh, Arkasubhra
Jayadev, Chaitra
Nagaraja, Harsha
An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus
title An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus
title_full An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus
title_fullStr An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus
title_full_unstemmed An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus
title_short An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus
title_sort in vivo confocal microscopic study of corneal nerve morphology in unilateral keratoconus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745354/
https://www.ncbi.nlm.nih.gov/pubmed/26904679
http://dx.doi.org/10.1155/2016/5067853
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