Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase

Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune d...

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Detalles Bibliográficos
Autores principales: Odobasic, Dragana, Kitching, A. Richard, Holdsworth, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745373/
https://www.ncbi.nlm.nih.gov/pubmed/26904693
http://dx.doi.org/10.1155/2016/2349817
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author Odobasic, Dragana
Kitching, A. Richard
Holdsworth, Stephen R.
author_facet Odobasic, Dragana
Kitching, A. Richard
Holdsworth, Stephen R.
author_sort Odobasic, Dragana
collection PubMed
description Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.
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spelling pubmed-47453732016-02-22 Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase Odobasic, Dragana Kitching, A. Richard Holdsworth, Stephen R. J Immunol Res Review Article Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity. Hindawi Publishing Corporation 2016 2016-01-20 /pmc/articles/PMC4745373/ /pubmed/26904693 http://dx.doi.org/10.1155/2016/2349817 Text en Copyright © 2016 Dragana Odobasic et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Odobasic, Dragana
Kitching, A. Richard
Holdsworth, Stephen R.
Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase
title Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase
title_full Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase
title_fullStr Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase
title_full_unstemmed Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase
title_short Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase
title_sort neutrophil-mediated regulation of innate and adaptive immunity: the role of myeloperoxidase
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745373/
https://www.ncbi.nlm.nih.gov/pubmed/26904693
http://dx.doi.org/10.1155/2016/2349817
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