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Preparation, Biological Evaluation and Dosimetry Studies of 175Yb-Bis-Phosphonates for Palliative Treatment of Bone Pain
OBJECTIVE: Optimized production and quality control of ytterbium-175 (Yb-175) labeled pamidronate and alendronate complexes as efficient agents for bone pain palliation has been presented. METHODS: Yb-175 labeled pamidronate and alendronate (175Yb-PMD and 175Yb-ALN) complexes were prepared successfu...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745403/ https://www.ncbi.nlm.nih.gov/pubmed/27529886 http://dx.doi.org/10.4274/mirt.36036 |
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author | Fakhari, Ashraf Jalilian, Amir R. Yousefnia, Hassan Shanehsazzadeh, Saeed Samani, Ali Bahrami Daha, Fariba Johari Ardestani, Mehdi Shafiee Khalaj, Ali |
author_facet | Fakhari, Ashraf Jalilian, Amir R. Yousefnia, Hassan Shanehsazzadeh, Saeed Samani, Ali Bahrami Daha, Fariba Johari Ardestani, Mehdi Shafiee Khalaj, Ali |
author_sort | Fakhari, Ashraf |
collection | PubMed |
description | OBJECTIVE: Optimized production and quality control of ytterbium-175 (Yb-175) labeled pamidronate and alendronate complexes as efficient agents for bone pain palliation has been presented. METHODS: Yb-175 labeled pamidronate and alendronate (175Yb-PMD and 175Yb-ALN) complexes were prepared successfully at optimized conditions with acceptable radiochemical purity, stability and significant hydroxyapatite absorption. The biodistribution of complexes were evaluated up to 48 h, which demonstrated significant bone uptake ratios for 175Yb-PAM at all-time intervals. It was also detected that 175Yb-PAM mostly washed out and excreted through the kidneys. RESULTS: The performance of 175Yb-PAM in an animal model was better or comparable to other 175Yb-bone seeking complexes previously reported. CONCLUSION: Based on calculations, the total body dose for 175Yb-ALN is 40% higher as compared to 175Yb-PAM (especially kidneys) indicating that 175Yb-PAM is probably a safer agent than 175Yb-ALN. |
format | Online Article Text |
id | pubmed-4745403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-47454032016-02-18 Preparation, Biological Evaluation and Dosimetry Studies of 175Yb-Bis-Phosphonates for Palliative Treatment of Bone Pain Fakhari, Ashraf Jalilian, Amir R. Yousefnia, Hassan Shanehsazzadeh, Saeed Samani, Ali Bahrami Daha, Fariba Johari Ardestani, Mehdi Shafiee Khalaj, Ali Mol Imaging Radionucl Ther Original Article OBJECTIVE: Optimized production and quality control of ytterbium-175 (Yb-175) labeled pamidronate and alendronate complexes as efficient agents for bone pain palliation has been presented. METHODS: Yb-175 labeled pamidronate and alendronate (175Yb-PMD and 175Yb-ALN) complexes were prepared successfully at optimized conditions with acceptable radiochemical purity, stability and significant hydroxyapatite absorption. The biodistribution of complexes were evaluated up to 48 h, which demonstrated significant bone uptake ratios for 175Yb-PAM at all-time intervals. It was also detected that 175Yb-PAM mostly washed out and excreted through the kidneys. RESULTS: The performance of 175Yb-PAM in an animal model was better or comparable to other 175Yb-bone seeking complexes previously reported. CONCLUSION: Based on calculations, the total body dose for 175Yb-ALN is 40% higher as compared to 175Yb-PAM (especially kidneys) indicating that 175Yb-PAM is probably a safer agent than 175Yb-ALN. Galenos Publishing 2015-10 2015-11-02 /pmc/articles/PMC4745403/ /pubmed/27529886 http://dx.doi.org/10.4274/mirt.36036 Text en © Molecular Imaging and Radionuclide Therapy, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Fakhari, Ashraf Jalilian, Amir R. Yousefnia, Hassan Shanehsazzadeh, Saeed Samani, Ali Bahrami Daha, Fariba Johari Ardestani, Mehdi Shafiee Khalaj, Ali Preparation, Biological Evaluation and Dosimetry Studies of 175Yb-Bis-Phosphonates for Palliative Treatment of Bone Pain |
title | Preparation, Biological Evaluation and Dosimetry Studies of 175Yb-Bis-Phosphonates for Palliative Treatment of Bone Pain |
title_full | Preparation, Biological Evaluation and Dosimetry Studies of 175Yb-Bis-Phosphonates for Palliative Treatment of Bone Pain |
title_fullStr | Preparation, Biological Evaluation and Dosimetry Studies of 175Yb-Bis-Phosphonates for Palliative Treatment of Bone Pain |
title_full_unstemmed | Preparation, Biological Evaluation and Dosimetry Studies of 175Yb-Bis-Phosphonates for Palliative Treatment of Bone Pain |
title_short | Preparation, Biological Evaluation and Dosimetry Studies of 175Yb-Bis-Phosphonates for Palliative Treatment of Bone Pain |
title_sort | preparation, biological evaluation and dosimetry studies of 175yb-bis-phosphonates for palliative treatment of bone pain |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745403/ https://www.ncbi.nlm.nih.gov/pubmed/27529886 http://dx.doi.org/10.4274/mirt.36036 |
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