TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases

NF-κB activation depends on the IKK complex consisting of the catalytically active IKK1 and 2 subunits and the scaffold protein NEMO. Hitherto, IKK2 activation has always been associated with IκBα degradation, NF-κB activation, and cytokine production. In contrast, we found that in SCF-stimulated pr...

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Detalles Bibliográficos
Autores principales: Drube, Sebastian, Weber, Franziska, Göpfert, Christiane, Loschinski, Romy, Rothe, Mandy, Boelke, Franziska, Diamanti, Michaela A., Löhn, Tobias, Ruth, Julia, Schütz, Dagmar, Häfner, Norman, Greten, Florian R., Stumm, Ralf, Hartmann, Karin, Krämer, Oliver H., Dudeck, Anne, Kamradt, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745695/
https://www.ncbi.nlm.nih.gov/pubmed/26353931

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