Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor

Using lentiviral technology, we recently demonstrated that incorporation of CD27 costimulation into CARs greatly improves antitumor activity and T cell persistence. Still, virus-mediated gene transfer is expensive, laborious and enables long-term persistence, creating therapies which cannot be easil...

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Detalles Bibliográficos
Autores principales: Schutsky, Keith, Song, De-Gang, Lynn, Rachel, Smith, Jenessa B., Poussin, Mathilde, Figini, Mariangela, Zhao, Yangbing, Powell, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745700/
https://www.ncbi.nlm.nih.gov/pubmed/26359629

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