PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer

The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial–mesenchymal transition. JunB levels were increased in GBC samples an...

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Detalles Bibliográficos
Autores principales: Lian, Shixian, Shao, Yebo, Liu, Houbao, He, Junyi, Lu, Weiqi, Zhang, Yong, Jiang, Ying, Zhu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745712/
https://www.ncbi.nlm.nih.gov/pubmed/26318166
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author Lian, Shixian
Shao, Yebo
Liu, Houbao
He, Junyi
Lu, Weiqi
Zhang, Yong
Jiang, Ying
Zhu, Jun
author_facet Lian, Shixian
Shao, Yebo
Liu, Houbao
He, Junyi
Lu, Weiqi
Zhang, Yong
Jiang, Ying
Zhu, Jun
author_sort Lian, Shixian
collection PubMed
description The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial–mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.
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spelling pubmed-47457122016-02-23 PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer Lian, Shixian Shao, Yebo Liu, Houbao He, Junyi Lu, Weiqi Zhang, Yong Jiang, Ying Zhu, Jun Oncotarget Research Paper The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial–mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB. Impact Journals LLC 2015-08-05 /pmc/articles/PMC4745712/ /pubmed/26318166 Text en Copyright: © 2015 Lian et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Lian, Shixian
Shao, Yebo
Liu, Houbao
He, Junyi
Lu, Weiqi
Zhang, Yong
Jiang, Ying
Zhu, Jun
PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer
title PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer
title_full PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer
title_fullStr PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer
title_full_unstemmed PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer
title_short PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer
title_sort pdk1 induces junb, emt, cell migration and invasion in human gallbladder cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745712/
https://www.ncbi.nlm.nih.gov/pubmed/26318166
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