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Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer
Massive genomic rearrangements, a result of single catastrophic event termed chromothrispsis or chromosomal catastrophe, have been identified in a variety of human cancers. In a few cancer types, chromothripsis was found to be associated with poor prognosis. We performed mate-pair sequencing and ana...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745713/ https://www.ncbi.nlm.nih.gov/pubmed/26337081 |
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author | Kovtun, Irina V. Murphy, Stephen J. Johnson, Sarah H. Cheville, John C. Vasmatzis, George |
author_facet | Kovtun, Irina V. Murphy, Stephen J. Johnson, Sarah H. Cheville, John C. Vasmatzis, George |
author_sort | Kovtun, Irina V. |
collection | PubMed |
description | Massive genomic rearrangements, a result of single catastrophic event termed chromothrispsis or chromosomal catastrophe, have been identified in a variety of human cancers. In a few cancer types, chromothripsis was found to be associated with poor prognosis. We performed mate-pair sequencing and analysis of structural rearrangements in 132 prostate cancer cases which included clinically insignificant Gleason score 6 tumors, clinically significant tumors of higher grade (7+) and high grade prostatic intraepithelial neoplasia. Chromothripsis was observed at least 30 per cent of the samples across different grades. Surprisingly, it was frequently observed in clinically insignificant Gleason score 6 tumors, indicating that chromothripsis does not define more aggressive phenotype. The degree of chromothripsis did not increase significantly in tumors of advanced grades and did not appear to contribute to tumor progression. Our data showed that distribution of chromothriptic rearrangements differed from that of fragile sites but correlated with the size of chromosomes. We also provided evidence that rearrangements resulting from chromothripsis were present in the cells of neighboring Gleason patterns of the same tumor. Our data suggest that that chromothripsis plays role in prostate cancer initiation. |
format | Online Article Text |
id | pubmed-4745713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-47457132016-02-23 Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer Kovtun, Irina V. Murphy, Stephen J. Johnson, Sarah H. Cheville, John C. Vasmatzis, George Oncotarget Research Paper Massive genomic rearrangements, a result of single catastrophic event termed chromothrispsis or chromosomal catastrophe, have been identified in a variety of human cancers. In a few cancer types, chromothripsis was found to be associated with poor prognosis. We performed mate-pair sequencing and analysis of structural rearrangements in 132 prostate cancer cases which included clinically insignificant Gleason score 6 tumors, clinically significant tumors of higher grade (7+) and high grade prostatic intraepithelial neoplasia. Chromothripsis was observed at least 30 per cent of the samples across different grades. Surprisingly, it was frequently observed in clinically insignificant Gleason score 6 tumors, indicating that chromothripsis does not define more aggressive phenotype. The degree of chromothripsis did not increase significantly in tumors of advanced grades and did not appear to contribute to tumor progression. Our data showed that distribution of chromothriptic rearrangements differed from that of fragile sites but correlated with the size of chromosomes. We also provided evidence that rearrangements resulting from chromothripsis were present in the cells of neighboring Gleason patterns of the same tumor. Our data suggest that that chromothripsis plays role in prostate cancer initiation. Impact Journals LLC 2015-08-21 /pmc/articles/PMC4745713/ /pubmed/26337081 Text en Copyright: © 2015 Kovtun et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Kovtun, Irina V. Murphy, Stephen J. Johnson, Sarah H. Cheville, John C. Vasmatzis, George Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer |
title | Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer |
title_full | Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer |
title_fullStr | Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer |
title_full_unstemmed | Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer |
title_short | Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer |
title_sort | chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745713/ https://www.ncbi.nlm.nih.gov/pubmed/26337081 |
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