MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN

MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer (NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells. We found that miRNA-10a was up-regulated in NSCLC compared with corresponding no...

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Detalles Bibliográficos
Autores principales: Yu, Tao, Liu, Lei, Li, Jing, Yan, Mingxia, Lin, Hechun, Liu, Ying, Chu, Dandan, Tu, Hong, Gu, Aiqin, Yao, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745794/
https://www.ncbi.nlm.nih.gov/pubmed/26317552
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author Yu, Tao
Liu, Lei
Li, Jing
Yan, Mingxia
Lin, Hechun
Liu, Ying
Chu, Dandan
Tu, Hong
Gu, Aiqin
Yao, Ming
author_facet Yu, Tao
Liu, Lei
Li, Jing
Yan, Mingxia
Lin, Hechun
Liu, Ying
Chu, Dandan
Tu, Hong
Gu, Aiqin
Yao, Ming
author_sort Yu, Tao
collection PubMed
description MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer (NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells. We found that miRNA-10a was up-regulated in NSCLC compared with corresponding normal tissues. High expression of miR-10a was associated with tumor node metastasis and lymph node metastasis. Furthermore, overexpression of miR-10a promoted NSCLC cell proliferation, migration and invasion in vitro. We found that PTEN was a direct target of miR-10a in NSCLC. Also miR-10a activated the PTEN/AKT/ERK pathway. We suggest that miR-10a contributes to NSCLC by targeting PTEN.
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spelling pubmed-47457942016-02-23 MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN Yu, Tao Liu, Lei Li, Jing Yan, Mingxia Lin, Hechun Liu, Ying Chu, Dandan Tu, Hong Gu, Aiqin Yao, Ming Oncotarget Research Paper MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer (NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells. We found that miRNA-10a was up-regulated in NSCLC compared with corresponding normal tissues. High expression of miR-10a was associated with tumor node metastasis and lymph node metastasis. Furthermore, overexpression of miR-10a promoted NSCLC cell proliferation, migration and invasion in vitro. We found that PTEN was a direct target of miR-10a in NSCLC. Also miR-10a activated the PTEN/AKT/ERK pathway. We suggest that miR-10a contributes to NSCLC by targeting PTEN. Impact Journals LLC 2015-07-22 /pmc/articles/PMC4745794/ /pubmed/26317552 Text en Copyright: © 2015 Yu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Yu, Tao
Liu, Lei
Li, Jing
Yan, Mingxia
Lin, Hechun
Liu, Ying
Chu, Dandan
Tu, Hong
Gu, Aiqin
Yao, Ming
MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN
title MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN
title_full MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN
title_fullStr MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN
title_full_unstemmed MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN
title_short MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN
title_sort mirna-10a is upregulated in nsclc and may promote cancer by targeting pten
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745794/
https://www.ncbi.nlm.nih.gov/pubmed/26317552
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