Cargando…

Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control

Genome-wide association studies (GWAS) have identified over 40 type 1 diabetes risk loci. The clinical impact of these loci on β-cell function during disease progression is unknown. We aimed at testing whether a genetic risk score could predict glycemic control and residual β-cell function in type 1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brorsson, Caroline A., Nielsen, Lotte B., Andersen, Marie Louise, Kaur, Simranjeet, Bergholdt, Regine, Hansen, Lars, Mortensen, Henrik B., Pociot, Flemming, Størling, Joachim, Hvidoere Study Group on Childhood Diabetes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745814/ https://www.ncbi.nlm.nih.gov/pubmed/26904692 http://dx.doi.org/10.1155/2016/9570424

Ejemplares similares

A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets
por: Kaur, Simranjeet, et al.
Publicado: (2021)

Expression Profiling of Human Genetic and Protein Interaction Networks in Type 1 Diabetes
por: Bergholdt, Regine, et al.
Publicado: (2009)

Effects of GWAS-Associated Genetic Variants on lncRNAs within IBD and T1D Candidate Loci
por: Mirza, Aashiq H., et al.
Publicado: (2014)

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
por: Bergholdt, Regine, et al.
Publicado: (2012)

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients
por: Fløyel, Tina, et al.
Publicado: (2021)

Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes
por: Brorsson, Caroline A., et al.
Publicado: (2015)

The Type 1 Diabetes - HLA Susceptibility Interactome - Identification of HLA Genotype-Specific Disease Genes for Type 1 Diabetes
por: Brorsson, Caroline, et al.
Publicado: (2010)

Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets
por: Kaur, Simranjeet, et al.
Publicado: (2018)

Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis
por: Størling, Joachim, et al.
Publicado: (2017)

No Difference in Vitamin D Levels Between Children Newly Diagnosed With Type 1 Diabetes and Their Healthy Siblings: A 13-Year Nationwide Danish Study
por: Thorsen, Steffen U., et al.
Publicado: (2013)

Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs
por: Mirza, Aashiq H., et al.
Publicado: (2019)

Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?
por: Kaur, Simranjeet, et al.
Publicado: (2015)

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period
por: Frørup, Caroline, et al.
Publicado: (2021)

Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes
por: Samandari, Nasim, et al.
Publicado: (2018)

Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining
por: Kirk, Isa Kristina, et al.
Publicado: (2019)

Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
por: Bergholdt, Regine, et al.
Publicado: (2007)

Genetic Variants Associated with Neuropeptide Y Autoantibody Levels in Newly Diagnosed Individuals with Type 1 Diabetes
por: Mansachs, Sara Juul, et al.
Publicado: (2022)

Long non-coding RNAs as novel players in β cell function and type 1 diabetes
por: Mirza, Aashiq H., et al.
Publicado: (2017)

The emerging role of lncRNAs in inflammatory bowel disease
por: Yarani, Reza, et al.
Publicado: (2018)

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
por: Kaur, Simranjeet, et al.
Publicado: (2022)

Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells
por: Frørup, Caroline, et al.
Publicado: (2023)

Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity
por: Pedersen, Kristina, et al.
Publicado: (2021)

Cathepsin C Regulates Cytokine-Induced Apoptosis in β-Cell Model Systems
por: Fløyel, Tina, et al.
Publicado: (2021)

Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes
por: Rudman, Najda, et al.
Publicado: (2023)

Abnormal islet sphingolipid metabolism in type 1 diabetes
por: Holm, Laurits J., et al.
Publicado: (2018)

Systemic TNFα correlates with residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes
por: Overgaard, Anne Julie, et al.
Publicado: (2020)

Low-grade inflammation in type 2 diabetes: a cross-sectional study from a Danish diabetes outpatient clinic
por: Okdahl, Tina, et al.
Publicado: (2022)

Children at onset of type 1 diabetes show altered N-glycosylation of plasma proteins and IgG
por: Rudman, Najda, et al.
Publicado: (2022)

Characterization of plasma lipidomics in adolescent subjects with increased risk for type 1 diabetes in the DiPiS cohort
por: Andersson Svärd, Agnes, et al.
Publicado: (2020)

Greater Glycemic Burden Is Associated with Further Poorer Glycemic Control in Newly-Diagnosed Type 2 Diabetes Mellitus Patients
por: Wen, Wei-Lun, et al.
Publicado: (2022)

Complex Multi-Block Analysis Identifies New Immunologic and Genetic Disease Progression Patterns Associated with the Residual β-Cell Function 1 Year after Diagnosis of Type 1 Diabetes
por: Andersen, Marie Louise Max, et al.
Publicado: (2013)

Polymorphisms in the Innate Immune IFIH1 Gene, Frequency of Enterovirus in Monthly Fecal Samples during Infancy, and Islet Autoimmunity
por: Witsø, Elisabet, et al.
Publicado: (2011)

Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)
por: Boesgaard, Trine W, et al.
Publicado: (2010)

Long-term Effect of Islet Transplantation on Glycemic Variability
por: Bertuzzi, Federico, et al.
Publicado: (2018)

MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage
por: Lindeløv Vestergaard, Anna, et al.
Publicado: (2018)

Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes
por: Wegeberg, Anne-Marie L., et al.
Publicado: (2020)

Food Insecurity Is Associated With Poorer Glycemic Control in Patients Receiving Free Versus Fee-Based Care
por: Holben, David H., et al.
Publicado: (2019)

Phenotypic Description of the Spanish Multicentre Genetic Glaucoma Group Cohort
por: Milla, Elena, et al.
Publicado: (2017)

Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression
por: Nielsen, Lotte B., et al.
Publicado: (2012)

Erratum to “Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression”
por: Nielsen, Lotte B., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_dac3no574gt97hkn9fuuhpo64b