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Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis

Neuroleptics can induce not only physical adverse effects but also mental effects that produce deficit status in thought, affect, cognition, and behavior. This condition is known as neuroleptic-induced deficit syndrome (NIDS), which includes apathy, lack of initiative, anhedonia, indifference, blunt...

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Autores principales: Ueda, Satoshi, Sakayori, Takeshi, Omori, Ataru, Fukuta, Hajime, Kobayashi, Takashi, Ishizaka, Kousuke, Saijo, Tomoyuki, Okubo, Yoshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745952/
https://www.ncbi.nlm.nih.gov/pubmed/26893564
http://dx.doi.org/10.2147/NDT.S99577
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author Ueda, Satoshi
Sakayori, Takeshi
Omori, Ataru
Fukuta, Hajime
Kobayashi, Takashi
Ishizaka, Kousuke
Saijo, Tomoyuki
Okubo, Yoshiro
author_facet Ueda, Satoshi
Sakayori, Takeshi
Omori, Ataru
Fukuta, Hajime
Kobayashi, Takashi
Ishizaka, Kousuke
Saijo, Tomoyuki
Okubo, Yoshiro
author_sort Ueda, Satoshi
collection PubMed
description Neuroleptics can induce not only physical adverse effects but also mental effects that produce deficit status in thought, affect, cognition, and behavior. This condition is known as neuroleptic-induced deficit syndrome (NIDS), which includes apathy, lack of initiative, anhedonia, indifference, blunted affect, and reduced insight into disease. Although this old concept now appears almost forgotten, neuroleptics, whether typical or atypical, can make depression or bipolar disorder resemble other more refractory conditions, readily leading to mistaken diagnosis and inappropriate treatment. The authors describe three cases of NIDS superimposed on depressive phase in bipolar disorder with psychosis, where the attending psychiatrist’s failure to recognize NIDS prevented patients from receiving effective treatment and achieving remission. All cases achieved remission after reduction of neuroleptics and intensive therapy, including electroconvulsive therapy, for bipolar depression. The concept of NIDS was originally introduced for schizophrenia, and it has rarely been highlighted in other diseases. In recent years, however, atypical antipsychotics are being more often administered to patients with bipolar disorder. Psychiatrists, therefore, should also remember and exercise caution regarding NIDS in the pharmacotherapy of bipolar disorder with and without psychosis. The authors believe that the concept of NIDS needs to be reappraised in current psychiatry.
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spelling pubmed-47459522016-02-18 Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis Ueda, Satoshi Sakayori, Takeshi Omori, Ataru Fukuta, Hajime Kobayashi, Takashi Ishizaka, Kousuke Saijo, Tomoyuki Okubo, Yoshiro Neuropsychiatr Dis Treat Case Series Neuroleptics can induce not only physical adverse effects but also mental effects that produce deficit status in thought, affect, cognition, and behavior. This condition is known as neuroleptic-induced deficit syndrome (NIDS), which includes apathy, lack of initiative, anhedonia, indifference, blunted affect, and reduced insight into disease. Although this old concept now appears almost forgotten, neuroleptics, whether typical or atypical, can make depression or bipolar disorder resemble other more refractory conditions, readily leading to mistaken diagnosis and inappropriate treatment. The authors describe three cases of NIDS superimposed on depressive phase in bipolar disorder with psychosis, where the attending psychiatrist’s failure to recognize NIDS prevented patients from receiving effective treatment and achieving remission. All cases achieved remission after reduction of neuroleptics and intensive therapy, including electroconvulsive therapy, for bipolar depression. The concept of NIDS was originally introduced for schizophrenia, and it has rarely been highlighted in other diseases. In recent years, however, atypical antipsychotics are being more often administered to patients with bipolar disorder. Psychiatrists, therefore, should also remember and exercise caution regarding NIDS in the pharmacotherapy of bipolar disorder with and without psychosis. The authors believe that the concept of NIDS needs to be reappraised in current psychiatry. Dove Medical Press 2016-02-02 /pmc/articles/PMC4745952/ /pubmed/26893564 http://dx.doi.org/10.2147/NDT.S99577 Text en © 2016 Ueda et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Series
Ueda, Satoshi
Sakayori, Takeshi
Omori, Ataru
Fukuta, Hajime
Kobayashi, Takashi
Ishizaka, Kousuke
Saijo, Tomoyuki
Okubo, Yoshiro
Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title_full Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title_fullStr Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title_full_unstemmed Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title_short Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title_sort neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745952/
https://www.ncbi.nlm.nih.gov/pubmed/26893564
http://dx.doi.org/10.2147/NDT.S99577
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