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Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments

The aim of cardiovascular regeneration is to mimic the biological and mechanical functioning of tissues. For this it is crucial to recapitulate the in vivo cellular organization, which is the result of controlled cellular orientation. Cellular orientation response stems from the interaction between...

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Autores principales: Tamiello, Chiara, Buskermolen, Antonetta B. C., Baaijens, Frank P. T., Broers, Jos L. V., Bouten, Carlijn V. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746215/
https://www.ncbi.nlm.nih.gov/pubmed/26900408
http://dx.doi.org/10.1007/s12195-015-0422-7
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author Tamiello, Chiara
Buskermolen, Antonetta B. C.
Baaijens, Frank P. T.
Broers, Jos L. V.
Bouten, Carlijn V. C.
author_facet Tamiello, Chiara
Buskermolen, Antonetta B. C.
Baaijens, Frank P. T.
Broers, Jos L. V.
Bouten, Carlijn V. C.
author_sort Tamiello, Chiara
collection PubMed
description The aim of cardiovascular regeneration is to mimic the biological and mechanical functioning of tissues. For this it is crucial to recapitulate the in vivo cellular organization, which is the result of controlled cellular orientation. Cellular orientation response stems from the interaction between the cell and its complex biophysical environment. Environmental biophysical cues are continuously detected and transduced to the nucleus through entwined mechanotransduction pathways. Next to the biochemical cascades invoked by the mechanical stimuli, the structural mechanotransduction pathway made of focal adhesions and the actin cytoskeleton can quickly transduce the biophysical signals directly to the nucleus. Observations linking cellular orientation response to biophysical cues have pointed out that the anisotropy and cyclic straining of the substrate influence cellular orientation. Yet, little is known about the mechanisms governing cellular orientation responses in case of cues applied separately and in combination. This review provides the state-of-the-art knowledge on the structural mechanotransduction pathway of adhesive cells, followed by an overview of the current understanding of cellular orientation responses to substrate anisotropy and uniaxial cyclic strain. Finally, we argue that comprehensive understanding of cellular orientation in complex biophysical environments requires systematic approaches based on the dissection of (sub)cellular responses to the individual cues composing the biophysical niche.
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spelling pubmed-47462152016-02-18 Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments Tamiello, Chiara Buskermolen, Antonetta B. C. Baaijens, Frank P. T. Broers, Jos L. V. Bouten, Carlijn V. C. Cell Mol Bioeng Article The aim of cardiovascular regeneration is to mimic the biological and mechanical functioning of tissues. For this it is crucial to recapitulate the in vivo cellular organization, which is the result of controlled cellular orientation. Cellular orientation response stems from the interaction between the cell and its complex biophysical environment. Environmental biophysical cues are continuously detected and transduced to the nucleus through entwined mechanotransduction pathways. Next to the biochemical cascades invoked by the mechanical stimuli, the structural mechanotransduction pathway made of focal adhesions and the actin cytoskeleton can quickly transduce the biophysical signals directly to the nucleus. Observations linking cellular orientation response to biophysical cues have pointed out that the anisotropy and cyclic straining of the substrate influence cellular orientation. Yet, little is known about the mechanisms governing cellular orientation responses in case of cues applied separately and in combination. This review provides the state-of-the-art knowledge on the structural mechanotransduction pathway of adhesive cells, followed by an overview of the current understanding of cellular orientation responses to substrate anisotropy and uniaxial cyclic strain. Finally, we argue that comprehensive understanding of cellular orientation in complex biophysical environments requires systematic approaches based on the dissection of (sub)cellular responses to the individual cues composing the biophysical niche. Springer US 2015-11-02 2016 /pmc/articles/PMC4746215/ /pubmed/26900408 http://dx.doi.org/10.1007/s12195-015-0422-7 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Tamiello, Chiara
Buskermolen, Antonetta B. C.
Baaijens, Frank P. T.
Broers, Jos L. V.
Bouten, Carlijn V. C.
Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments
title Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments
title_full Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments
title_fullStr Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments
title_full_unstemmed Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments
title_short Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments
title_sort heading in the right direction: understanding cellular orientation responses to complex biophysical environments
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746215/
https://www.ncbi.nlm.nih.gov/pubmed/26900408
http://dx.doi.org/10.1007/s12195-015-0422-7
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