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Fibronectin Mechanobiology Regulates Tumorigenesis

Fibronectin (Fn) is an essential extracellular matrix (ECM) glycoprotein involved in both physiological and pathological processes. The structure–function relationship of Fn has been and is still being studied, as changes in its molecular structure are integral in regulating (or dysregulating) its b...

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Autores principales: Wang, Karin, Seo, Bo Ri, Fischbach, Claudia, Gourdon, Delphine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746220/
https://www.ncbi.nlm.nih.gov/pubmed/26900407
http://dx.doi.org/10.1007/s12195-015-0417-4
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author Wang, Karin
Seo, Bo Ri
Fischbach, Claudia
Gourdon, Delphine
author_facet Wang, Karin
Seo, Bo Ri
Fischbach, Claudia
Gourdon, Delphine
author_sort Wang, Karin
collection PubMed
description Fibronectin (Fn) is an essential extracellular matrix (ECM) glycoprotein involved in both physiological and pathological processes. The structure–function relationship of Fn has been and is still being studied, as changes in its molecular structure are integral in regulating (or dysregulating) its biological activities via its cell, matrix component, and growth factor binding sites. Fn comprises three types of repeating modules; among them, FnIII modules are mechanically unstable domains that may be extended/unfolded upon cell traction and either uncover cryptic binding sites or disrupt otherwise exposed binding sites. Cells assemble Fn into a fibrillar network; its conformational flexibility implicates Fn as a critical mechanoregulator of the ECM. Fn has been shown to contribute to altered stroma remodeling during tumorigenesis. This review will discuss (i) the significance of the structure–function relationship of Fn at both the molecular and the matrix scales, (ii) the role of Fn mechanobiology in the regulation of tumorigenesis, and (iii) Fn-related advances in cancer therapy development.
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spelling pubmed-47462202016-02-19 Fibronectin Mechanobiology Regulates Tumorigenesis Wang, Karin Seo, Bo Ri Fischbach, Claudia Gourdon, Delphine Cell Mol Bioeng Article Fibronectin (Fn) is an essential extracellular matrix (ECM) glycoprotein involved in both physiological and pathological processes. The structure–function relationship of Fn has been and is still being studied, as changes in its molecular structure are integral in regulating (or dysregulating) its biological activities via its cell, matrix component, and growth factor binding sites. Fn comprises three types of repeating modules; among them, FnIII modules are mechanically unstable domains that may be extended/unfolded upon cell traction and either uncover cryptic binding sites or disrupt otherwise exposed binding sites. Cells assemble Fn into a fibrillar network; its conformational flexibility implicates Fn as a critical mechanoregulator of the ECM. Fn has been shown to contribute to altered stroma remodeling during tumorigenesis. This review will discuss (i) the significance of the structure–function relationship of Fn at both the molecular and the matrix scales, (ii) the role of Fn mechanobiology in the regulation of tumorigenesis, and (iii) Fn-related advances in cancer therapy development. Springer US 2015-08-15 2016 /pmc/articles/PMC4746220/ /pubmed/26900407 http://dx.doi.org/10.1007/s12195-015-0417-4 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Wang, Karin
Seo, Bo Ri
Fischbach, Claudia
Gourdon, Delphine
Fibronectin Mechanobiology Regulates Tumorigenesis
title Fibronectin Mechanobiology Regulates Tumorigenesis
title_full Fibronectin Mechanobiology Regulates Tumorigenesis
title_fullStr Fibronectin Mechanobiology Regulates Tumorigenesis
title_full_unstemmed Fibronectin Mechanobiology Regulates Tumorigenesis
title_short Fibronectin Mechanobiology Regulates Tumorigenesis
title_sort fibronectin mechanobiology regulates tumorigenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746220/
https://www.ncbi.nlm.nih.gov/pubmed/26900407
http://dx.doi.org/10.1007/s12195-015-0417-4
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