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Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line
Periodontal disease represents a group of oral inflammatory infections initiated by oral pathogens which exist as a complex biofilms on the tooth surface and cause destruction to tooth supporting tissues. The severity of this disease ranges from mild and reversible inflammation of the gingiva (gingi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746253/ https://www.ncbi.nlm.nih.gov/pubmed/26903954 http://dx.doi.org/10.3389/fmicb.2016.00053 |
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author | How, Kah Yan Song, Keang Peng Chan, Kok Gan |
author_facet | How, Kah Yan Song, Keang Peng Chan, Kok Gan |
author_sort | How, Kah Yan |
collection | PubMed |
description | Periodontal disease represents a group of oral inflammatory infections initiated by oral pathogens which exist as a complex biofilms on the tooth surface and cause destruction to tooth supporting tissues. The severity of this disease ranges from mild and reversible inflammation of the gingiva (gingivitis) to chronic destruction of connective tissues, the formation of periodontal pocket and ultimately result in loss of teeth. While human subgingival plaque harbors more than 500 bacterial species, considerable research has shown that Porphyromonas gingivalis, a Gram-negative anaerobic bacterium, is the major etiologic agent which contributes to chronic periodontitis. This black-pigmented bacterium produces a myriad of virulence factors that cause destruction to periodontal tissues either directly or indirectly by modulating the host inflammatory response. Here, this review provides an overview of P. gingivalis and how its virulence factors contribute to the pathogenesis with other microbiome consortium in oral cavity. |
format | Online Article Text |
id | pubmed-4746253 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47462532016-02-22 Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line How, Kah Yan Song, Keang Peng Chan, Kok Gan Front Microbiol Microbiology Periodontal disease represents a group of oral inflammatory infections initiated by oral pathogens which exist as a complex biofilms on the tooth surface and cause destruction to tooth supporting tissues. The severity of this disease ranges from mild and reversible inflammation of the gingiva (gingivitis) to chronic destruction of connective tissues, the formation of periodontal pocket and ultimately result in loss of teeth. While human subgingival plaque harbors more than 500 bacterial species, considerable research has shown that Porphyromonas gingivalis, a Gram-negative anaerobic bacterium, is the major etiologic agent which contributes to chronic periodontitis. This black-pigmented bacterium produces a myriad of virulence factors that cause destruction to periodontal tissues either directly or indirectly by modulating the host inflammatory response. Here, this review provides an overview of P. gingivalis and how its virulence factors contribute to the pathogenesis with other microbiome consortium in oral cavity. Frontiers Media S.A. 2016-02-09 /pmc/articles/PMC4746253/ /pubmed/26903954 http://dx.doi.org/10.3389/fmicb.2016.00053 Text en Copyright © 2016 How, Song and Chan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology How, Kah Yan Song, Keang Peng Chan, Kok Gan Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line |
title | Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line |
title_full | Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line |
title_fullStr | Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line |
title_full_unstemmed | Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line |
title_short | Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line |
title_sort | porphyromonas gingivalis: an overview of periodontopathic pathogen below the gum line |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746253/ https://www.ncbi.nlm.nih.gov/pubmed/26903954 http://dx.doi.org/10.3389/fmicb.2016.00053 |
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