Sertoli Cell-Only Syndrome: Behind the Genetic Scenes

Sertoli cell-only syndrome is defined by the complete absence of germ cells in testicular tissues and always results in male infertility. The aetiology often remains unknown. In this paper, we have investigated possible causes of Sertoli cell-only syndrome with a special focus on genetic causes. Our...

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Detalles Bibliográficos
Autores principales: Stouffs, Katrien, Gheldof, Alexander, Tournaye, Herman, Vandermaelen, Deborah, Bonduelle, Maryse, Lissens, Willy, Seneca, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746273/
https://www.ncbi.nlm.nih.gov/pubmed/26925412
http://dx.doi.org/10.1155/2016/6191307
Descripción
Sumario:Sertoli cell-only syndrome is defined by the complete absence of germ cells in testicular tissues and always results in male infertility. The aetiology often remains unknown. In this paper, we have investigated possible causes of Sertoli cell-only syndrome with a special focus on genetic causes. Our results show that, for a large part of the patients (>23% in an unselected group), the sex chromosomes are involved. The majority of patients had a Klinefelter syndrome, followed by patients with Yq microdeletions. Array comparative genomic hybridization in a selected group of “idiopathic patients” showed no known infertility related copy number variations.

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