Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

Activation of the AKT/mTOR cascade and overexpression of c-Met have been implicated in the development of human hepatocellular carcinoma (HCC). To elucidate the functional crosstalk between the two pathways, we generated a model characterized by the combined expression of activated AKT and c-Met in...

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Detalles Bibliográficos
Autores principales: Hu, Junjie, Che, Li, Li, Lei, Pilo, Maria G., Cigliano, Antonio, Ribback, Silvia, Li, Xiaolei, Latte, Gavinella, Mela, Marta, Evert, Matthias, Dombrowski, Frank, Zheng, Guohua, Chen, Xin, Calvisi, Diego F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746674/
https://www.ncbi.nlm.nih.gov/pubmed/26857837
http://dx.doi.org/10.1038/srep20484

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