Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region

The aim of this study is to investigate the folding reaction of human frataxin, whose deficiency causes the neurodegenerative disease Friedreich’s Ataxia (FRDA). The characterization of different conformational states would provide knowledge about how frataxin can be stabilized without altering its...

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Detalles Bibliográficos
Autores principales: Faraj, Santiago E., González-Lebrero, Rodolfo M., Roman, Ernesto A., Santos, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746760/
https://www.ncbi.nlm.nih.gov/pubmed/26856628
http://dx.doi.org/10.1038/srep20782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746760/
https://www.ncbi.nlm.nih.gov/pubmed/26856628
http://dx.doi.org/10.1038/srep20782

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