Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation

BACKGROUND: The insulin-like growth factor (IGF) system impacts cellular development by regulating proliferation, differentiation, and apoptosis, and is an attractive therapeutic target in cancer. The IGF system is complex, with two ligands (IGF1, IGF2), two receptors (IGF1R, IGF2R), and at least si...

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Detalles Bibliográficos
Autores principales: Tian, Dan, Mitchell, Isaiah, Kreeger, Pamela K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746774/
https://www.ncbi.nlm.nih.gov/pubmed/26861122
http://dx.doi.org/10.1186/s12918-016-0263-6

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