Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells

BACKGROUND: The majority of glioblastomas have aberrant receptor tyrosine kinase (RTK)/RAS/phosphoinositide 3 kinase (PI3K) signaling pathways and malignant glioma cells are thought to be addicted to these signaling pathways for their survival and proliferation. However, recent studies suggest that...

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Detalles Bibliográficos
Autores principales: Shingu, Takashi, Holmes, Lindsay, Henry, Verlene, Wang, Qianghu, Latha, Khatri, Gururaj, Anupama E., Gibson, Laura A., Doucette, Tiffany, Lang, Frederick F., Rao, Ganesh, Yuan, Liang, Sulman, Erik P., Farrell, Nicholas P., Priebe, Waldemar, Hess, Kenneth R., Wang, Yaoqi A., Hu, Jian, Bögler, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746796/
https://www.ncbi.nlm.nih.gov/pubmed/26861698
http://dx.doi.org/10.1186/s12967-016-0803-2

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