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Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

BACKGROUND: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising...

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Autores principales: Silvestri, Valentina, Barrowdale, Daniel, Mulligan, Anna Marie, Neuhausen, Susan L., Fox, Stephen, Karlan, Beth Y., Mitchell, Gillian, James, Paul, Thull, Darcy L., Zorn, Kristin K., Carter, Natalie J., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Ramus, Susan J., Nussbaum, Robert L., Olopade, Olufunmilayo I., Rantala, Johanna, Yoon, Sook-Yee, Caligo, Maria A., Spugnesi, Laura, Bojesen, Anders, Pedersen, Inge Sokilde, Thomassen, Mads, Jensen, Uffe Birk, Toland, Amanda Ewart, Senter, Leigha, Andrulis, Irene L., Glendon, Gord, Hulick, Peter J., Imyanitov, Evgeny N., Greene, Mark H., Mai, Phuong L., Singer, Christian F., Rappaport-Fuerhauser, Christine, Kramer, Gero, Vijai, Joseph, Offit, Kenneth, Robson, Mark, Lincoln, Anne, Jacobs, Lauren, Machackova, Eva, Foretova, Lenka, Navratilova, Marie, Vasickova, Petra, Couch, Fergus J., Hallberg, Emily, Ruddy, Kathryn J., Sharma, Priyanka, Kim, Sung-Won, Teixeira, Manuel R., Pinto, Pedro, Montagna, Marco, Matricardi, Laura, Arason, Adalgeir, Johannsson, Oskar Th, Barkardottir, Rosa B., Jakubowska, Anna, Lubinski, Jan, Izquierdo, Angel, Pujana, Miguel Angel, Balmaña, Judith, Diez, Orland, Ivady, Gabriella, Papp, Janos, Olah, Edith, Kwong, Ava, Nevanlinna, Heli, Aittomäki, Kristiina, Perez Segura, Pedro, Caldes, Trinidad, Van Maerken, Tom, Poppe, Bruce, Claes, Kathleen B. M., Isaacs, Claudine, Elan, Camille, Lasset, Christine, Stoppa-Lyonnet, Dominique, Barjhoux, Laure, Belotti, Muriel, Meindl, Alfons, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Hahnen, Eric, Kast, Karin, Arnold, Norbert, Varon-Mateeva, Raymonda, Wand, Dorothea, Godwin, Andrew K., Evans, D. Gareth, Frost, Debra, Perkins, Jo, Adlard, Julian, Izatt, Louise, Platte, Radka, Eeles, Ros, Ellis, Steve, Hamann, Ute, Garber, Judy, Fostira, Florentia, Fountzilas, George, Pasini, Barbara, Giannini, Giuseppe, Rizzolo, Piera, Russo, Antonio, Cortesi, Laura, Papi, Laura, Varesco, Liliana, Palli, Domenico, Zanna, Ines, Savarese, Antonella, Radice, Paolo, Manoukian, Siranoush, Peissel, Bernard, Barile, Monica, Bonanni, Bernardo, Viel, Alessandra, Pensotti, Valeria, Tommasi, Stefania, Peterlongo, Paolo, Weitzel, Jeffrey N., Osorio, Ana, Benitez, Javier, McGuffog, Lesley, Healey, Sue, Gerdes, Anne-Marie, Ejlertsen, Bent, Hansen, Thomas V. O., Steele, Linda, Ding, Yuan Chun, Tung, Nadine, Janavicius, Ramunas, Goldgar, David E., Buys, Saundra S., Daly, Mary B., Bane, Anita, Terry, Mary Beth, John, Esther M., Southey, Melissa, Easton, Douglas F., Chenevix-Trench, Georgia, Antoniou, Antonis C., Ottini, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746828/
https://www.ncbi.nlm.nih.gov/pubmed/26857456
http://dx.doi.org/10.1186/s13058-016-0671-y
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author Silvestri, Valentina
Barrowdale, Daniel
Mulligan, Anna Marie
Neuhausen, Susan L.
Fox, Stephen
Karlan, Beth Y.
Mitchell, Gillian
James, Paul
Thull, Darcy L.
Zorn, Kristin K.
Carter, Natalie J.
Nathanson, Katherine L.
Domchek, Susan M.
Rebbeck, Timothy R.
Ramus, Susan J.
Nussbaum, Robert L.
Olopade, Olufunmilayo I.
Rantala, Johanna
Yoon, Sook-Yee
Caligo, Maria A.
Spugnesi, Laura
Bojesen, Anders
Pedersen, Inge Sokilde
Thomassen, Mads
Jensen, Uffe Birk
Toland, Amanda Ewart
Senter, Leigha
Andrulis, Irene L.
Glendon, Gord
Hulick, Peter J.
Imyanitov, Evgeny N.
Greene, Mark H.
Mai, Phuong L.
Singer, Christian F.
Rappaport-Fuerhauser, Christine
Kramer, Gero
Vijai, Joseph
Offit, Kenneth
Robson, Mark
Lincoln, Anne
Jacobs, Lauren
Machackova, Eva
Foretova, Lenka
Navratilova, Marie
Vasickova, Petra
Couch, Fergus J.
Hallberg, Emily
Ruddy, Kathryn J.
Sharma, Priyanka
Kim, Sung-Won
Teixeira, Manuel R.
Pinto, Pedro
Montagna, Marco
Matricardi, Laura
Arason, Adalgeir
Johannsson, Oskar Th
Barkardottir, Rosa B.
Jakubowska, Anna
Lubinski, Jan
Izquierdo, Angel
Pujana, Miguel Angel
Balmaña, Judith
Diez, Orland
Ivady, Gabriella
Papp, Janos
Olah, Edith
Kwong, Ava
Nevanlinna, Heli
Aittomäki, Kristiina
Perez Segura, Pedro
Caldes, Trinidad
Van Maerken, Tom
Poppe, Bruce
Claes, Kathleen B. M.
Isaacs, Claudine
Elan, Camille
Lasset, Christine
Stoppa-Lyonnet, Dominique
Barjhoux, Laure
Belotti, Muriel
Meindl, Alfons
Gehrig, Andrea
Sutter, Christian
Engel, Christoph
Niederacher, Dieter
Steinemann, Doris
Hahnen, Eric
Kast, Karin
Arnold, Norbert
Varon-Mateeva, Raymonda
Wand, Dorothea
Godwin, Andrew K.
Evans, D. Gareth
Frost, Debra
Perkins, Jo
Adlard, Julian
Izatt, Louise
Platte, Radka
Eeles, Ros
Ellis, Steve
Hamann, Ute
Garber, Judy
Fostira, Florentia
Fountzilas, George
Pasini, Barbara
Giannini, Giuseppe
Rizzolo, Piera
Russo, Antonio
Cortesi, Laura
Papi, Laura
Varesco, Liliana
Palli, Domenico
Zanna, Ines
Savarese, Antonella
Radice, Paolo
Manoukian, Siranoush
Peissel, Bernard
Barile, Monica
Bonanni, Bernardo
Viel, Alessandra
Pensotti, Valeria
Tommasi, Stefania
Peterlongo, Paolo
Weitzel, Jeffrey N.
Osorio, Ana
Benitez, Javier
McGuffog, Lesley
Healey, Sue
Gerdes, Anne-Marie
Ejlertsen, Bent
Hansen, Thomas V. O.
Steele, Linda
Ding, Yuan Chun
Tung, Nadine
Janavicius, Ramunas
Goldgar, David E.
Buys, Saundra S.
Daly, Mary B.
Bane, Anita
Terry, Mary Beth
John, Esther M.
Southey, Melissa
Easton, Douglas F.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Ottini, Laura
author_facet Silvestri, Valentina
Barrowdale, Daniel
Mulligan, Anna Marie
Neuhausen, Susan L.
Fox, Stephen
Karlan, Beth Y.
Mitchell, Gillian
James, Paul
Thull, Darcy L.
Zorn, Kristin K.
Carter, Natalie J.
Nathanson, Katherine L.
Domchek, Susan M.
Rebbeck, Timothy R.
Ramus, Susan J.
Nussbaum, Robert L.
Olopade, Olufunmilayo I.
Rantala, Johanna
Yoon, Sook-Yee
Caligo, Maria A.
Spugnesi, Laura
Bojesen, Anders
Pedersen, Inge Sokilde
Thomassen, Mads
Jensen, Uffe Birk
Toland, Amanda Ewart
Senter, Leigha
Andrulis, Irene L.
Glendon, Gord
Hulick, Peter J.
Imyanitov, Evgeny N.
Greene, Mark H.
Mai, Phuong L.
Singer, Christian F.
Rappaport-Fuerhauser, Christine
Kramer, Gero
Vijai, Joseph
Offit, Kenneth
Robson, Mark
Lincoln, Anne
Jacobs, Lauren
Machackova, Eva
Foretova, Lenka
Navratilova, Marie
Vasickova, Petra
Couch, Fergus J.
Hallberg, Emily
Ruddy, Kathryn J.
Sharma, Priyanka
Kim, Sung-Won
Teixeira, Manuel R.
Pinto, Pedro
Montagna, Marco
Matricardi, Laura
Arason, Adalgeir
Johannsson, Oskar Th
Barkardottir, Rosa B.
Jakubowska, Anna
Lubinski, Jan
Izquierdo, Angel
Pujana, Miguel Angel
Balmaña, Judith
Diez, Orland
Ivady, Gabriella
Papp, Janos
Olah, Edith
Kwong, Ava
Nevanlinna, Heli
Aittomäki, Kristiina
Perez Segura, Pedro
Caldes, Trinidad
Van Maerken, Tom
Poppe, Bruce
Claes, Kathleen B. M.
Isaacs, Claudine
Elan, Camille
Lasset, Christine
Stoppa-Lyonnet, Dominique
Barjhoux, Laure
Belotti, Muriel
Meindl, Alfons
Gehrig, Andrea
Sutter, Christian
Engel, Christoph
Niederacher, Dieter
Steinemann, Doris
Hahnen, Eric
Kast, Karin
Arnold, Norbert
Varon-Mateeva, Raymonda
Wand, Dorothea
Godwin, Andrew K.
Evans, D. Gareth
Frost, Debra
Perkins, Jo
Adlard, Julian
Izatt, Louise
Platte, Radka
Eeles, Ros
Ellis, Steve
Hamann, Ute
Garber, Judy
Fostira, Florentia
Fountzilas, George
Pasini, Barbara
Giannini, Giuseppe
Rizzolo, Piera
Russo, Antonio
Cortesi, Laura
Papi, Laura
Varesco, Liliana
Palli, Domenico
Zanna, Ines
Savarese, Antonella
Radice, Paolo
Manoukian, Siranoush
Peissel, Bernard
Barile, Monica
Bonanni, Bernardo
Viel, Alessandra
Pensotti, Valeria
Tommasi, Stefania
Peterlongo, Paolo
Weitzel, Jeffrey N.
Osorio, Ana
Benitez, Javier
McGuffog, Lesley
Healey, Sue
Gerdes, Anne-Marie
Ejlertsen, Bent
Hansen, Thomas V. O.
Steele, Linda
Ding, Yuan Chun
Tung, Nadine
Janavicius, Ramunas
Goldgar, David E.
Buys, Saundra S.
Daly, Mary B.
Bane, Anita
Terry, Mary Beth
John, Esther M.
Southey, Melissa
Easton, Douglas F.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Ottini, Laura
author_sort Silvestri, Valentina
collection PubMed
description BACKGROUND: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). METHODS: We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10(−5)) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor–positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15–21.80] and progesterone receptor–positive (OR 5.04; 95 % CI 3.17–8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10(−12)). CONCLUSIONS: On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13058-016-0671-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-47468282016-02-10 Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 Silvestri, Valentina Barrowdale, Daniel Mulligan, Anna Marie Neuhausen, Susan L. Fox, Stephen Karlan, Beth Y. Mitchell, Gillian James, Paul Thull, Darcy L. Zorn, Kristin K. Carter, Natalie J. Nathanson, Katherine L. Domchek, Susan M. Rebbeck, Timothy R. Ramus, Susan J. Nussbaum, Robert L. Olopade, Olufunmilayo I. Rantala, Johanna Yoon, Sook-Yee Caligo, Maria A. Spugnesi, Laura Bojesen, Anders Pedersen, Inge Sokilde Thomassen, Mads Jensen, Uffe Birk Toland, Amanda Ewart Senter, Leigha Andrulis, Irene L. Glendon, Gord Hulick, Peter J. Imyanitov, Evgeny N. Greene, Mark H. Mai, Phuong L. Singer, Christian F. Rappaport-Fuerhauser, Christine Kramer, Gero Vijai, Joseph Offit, Kenneth Robson, Mark Lincoln, Anne Jacobs, Lauren Machackova, Eva Foretova, Lenka Navratilova, Marie Vasickova, Petra Couch, Fergus J. Hallberg, Emily Ruddy, Kathryn J. Sharma, Priyanka Kim, Sung-Won Teixeira, Manuel R. Pinto, Pedro Montagna, Marco Matricardi, Laura Arason, Adalgeir Johannsson, Oskar Th Barkardottir, Rosa B. Jakubowska, Anna Lubinski, Jan Izquierdo, Angel Pujana, Miguel Angel Balmaña, Judith Diez, Orland Ivady, Gabriella Papp, Janos Olah, Edith Kwong, Ava Nevanlinna, Heli Aittomäki, Kristiina Perez Segura, Pedro Caldes, Trinidad Van Maerken, Tom Poppe, Bruce Claes, Kathleen B. M. Isaacs, Claudine Elan, Camille Lasset, Christine Stoppa-Lyonnet, Dominique Barjhoux, Laure Belotti, Muriel Meindl, Alfons Gehrig, Andrea Sutter, Christian Engel, Christoph Niederacher, Dieter Steinemann, Doris Hahnen, Eric Kast, Karin Arnold, Norbert Varon-Mateeva, Raymonda Wand, Dorothea Godwin, Andrew K. Evans, D. Gareth Frost, Debra Perkins, Jo Adlard, Julian Izatt, Louise Platte, Radka Eeles, Ros Ellis, Steve Hamann, Ute Garber, Judy Fostira, Florentia Fountzilas, George Pasini, Barbara Giannini, Giuseppe Rizzolo, Piera Russo, Antonio Cortesi, Laura Papi, Laura Varesco, Liliana Palli, Domenico Zanna, Ines Savarese, Antonella Radice, Paolo Manoukian, Siranoush Peissel, Bernard Barile, Monica Bonanni, Bernardo Viel, Alessandra Pensotti, Valeria Tommasi, Stefania Peterlongo, Paolo Weitzel, Jeffrey N. Osorio, Ana Benitez, Javier McGuffog, Lesley Healey, Sue Gerdes, Anne-Marie Ejlertsen, Bent Hansen, Thomas V. O. Steele, Linda Ding, Yuan Chun Tung, Nadine Janavicius, Ramunas Goldgar, David E. Buys, Saundra S. Daly, Mary B. Bane, Anita Terry, Mary Beth John, Esther M. Southey, Melissa Easton, Douglas F. Chenevix-Trench, Georgia Antoniou, Antonis C. Ottini, Laura Breast Cancer Res Research Article BACKGROUND: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). METHODS: We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10(−5)) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor–positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15–21.80] and progesterone receptor–positive (OR 5.04; 95 % CI 3.17–8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10(−12)). CONCLUSIONS: On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13058-016-0671-y) contains supplementary material, which is available to authorized users. BioMed Central 2016-02-09 2016 /pmc/articles/PMC4746828/ /pubmed/26857456 http://dx.doi.org/10.1186/s13058-016-0671-y Text en © Silvestri et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Silvestri, Valentina
Barrowdale, Daniel
Mulligan, Anna Marie
Neuhausen, Susan L.
Fox, Stephen
Karlan, Beth Y.
Mitchell, Gillian
James, Paul
Thull, Darcy L.
Zorn, Kristin K.
Carter, Natalie J.
Nathanson, Katherine L.
Domchek, Susan M.
Rebbeck, Timothy R.
Ramus, Susan J.
Nussbaum, Robert L.
Olopade, Olufunmilayo I.
Rantala, Johanna
Yoon, Sook-Yee
Caligo, Maria A.
Spugnesi, Laura
Bojesen, Anders
Pedersen, Inge Sokilde
Thomassen, Mads
Jensen, Uffe Birk
Toland, Amanda Ewart
Senter, Leigha
Andrulis, Irene L.
Glendon, Gord
Hulick, Peter J.
Imyanitov, Evgeny N.
Greene, Mark H.
Mai, Phuong L.
Singer, Christian F.
Rappaport-Fuerhauser, Christine
Kramer, Gero
Vijai, Joseph
Offit, Kenneth
Robson, Mark
Lincoln, Anne
Jacobs, Lauren
Machackova, Eva
Foretova, Lenka
Navratilova, Marie
Vasickova, Petra
Couch, Fergus J.
Hallberg, Emily
Ruddy, Kathryn J.
Sharma, Priyanka
Kim, Sung-Won
Teixeira, Manuel R.
Pinto, Pedro
Montagna, Marco
Matricardi, Laura
Arason, Adalgeir
Johannsson, Oskar Th
Barkardottir, Rosa B.
Jakubowska, Anna
Lubinski, Jan
Izquierdo, Angel
Pujana, Miguel Angel
Balmaña, Judith
Diez, Orland
Ivady, Gabriella
Papp, Janos
Olah, Edith
Kwong, Ava
Nevanlinna, Heli
Aittomäki, Kristiina
Perez Segura, Pedro
Caldes, Trinidad
Van Maerken, Tom
Poppe, Bruce
Claes, Kathleen B. M.
Isaacs, Claudine
Elan, Camille
Lasset, Christine
Stoppa-Lyonnet, Dominique
Barjhoux, Laure
Belotti, Muriel
Meindl, Alfons
Gehrig, Andrea
Sutter, Christian
Engel, Christoph
Niederacher, Dieter
Steinemann, Doris
Hahnen, Eric
Kast, Karin
Arnold, Norbert
Varon-Mateeva, Raymonda
Wand, Dorothea
Godwin, Andrew K.
Evans, D. Gareth
Frost, Debra
Perkins, Jo
Adlard, Julian
Izatt, Louise
Platte, Radka
Eeles, Ros
Ellis, Steve
Hamann, Ute
Garber, Judy
Fostira, Florentia
Fountzilas, George
Pasini, Barbara
Giannini, Giuseppe
Rizzolo, Piera
Russo, Antonio
Cortesi, Laura
Papi, Laura
Varesco, Liliana
Palli, Domenico
Zanna, Ines
Savarese, Antonella
Radice, Paolo
Manoukian, Siranoush
Peissel, Bernard
Barile, Monica
Bonanni, Bernardo
Viel, Alessandra
Pensotti, Valeria
Tommasi, Stefania
Peterlongo, Paolo
Weitzel, Jeffrey N.
Osorio, Ana
Benitez, Javier
McGuffog, Lesley
Healey, Sue
Gerdes, Anne-Marie
Ejlertsen, Bent
Hansen, Thomas V. O.
Steele, Linda
Ding, Yuan Chun
Tung, Nadine
Janavicius, Ramunas
Goldgar, David E.
Buys, Saundra S.
Daly, Mary B.
Bane, Anita
Terry, Mary Beth
John, Esther M.
Southey, Melissa
Easton, Douglas F.
Chenevix-Trench, Georgia
Antoniou, Antonis C.
Ottini, Laura
Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
title Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
title_full Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
title_fullStr Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
title_full_unstemmed Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
title_short Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
title_sort male breast cancer in brca1 and brca2 mutation carriers: pathology data from the consortium of investigators of modifiers of brca1/2
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746828/
https://www.ncbi.nlm.nih.gov/pubmed/26857456
http://dx.doi.org/10.1186/s13058-016-0671-y
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AT thomassenmads malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT jensenuffebirk malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT tolandamandaewart malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT senterleigha malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT andrulisirenel malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT glendongord malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT hulickpeterj malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT imyanitovevgenyn malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT greenemarkh malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT maiphuongl malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT singerchristianf malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT rappaportfuerhauserchristine malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT kramergero malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT vijaijoseph malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT offitkenneth malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT robsonmark malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT lincolnanne malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT jacobslauren malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT machackovaeva malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT foretovalenka malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT navratilovamarie malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT vasickovapetra malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT couchfergusj malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT hallbergemily malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT ruddykathrynj malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT sharmapriyanka malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT kimsungwon malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT teixeiramanuelr malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT pintopedro malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT montagnamarco malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT matricardilaura malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT arasonadalgeir malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT johannssonoskarth malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT barkardottirrosab malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT jakubowskaanna malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT lubinskijan malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT izquierdoangel malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT pujanamiguelangel malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT balmanajudith malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT diezorland malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT ivadygabriella malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT pappjanos malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT olahedith malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT kwongava malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT nevanlinnaheli malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT aittomakikristiina malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT perezsegurapedro malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT caldestrinidad malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT vanmaerkentom malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT poppebruce malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT claeskathleenbm malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT isaacsclaudine malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT elancamille malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT lassetchristine malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT stoppalyonnetdominique malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT barjhouxlaure malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT belottimuriel malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT meindlalfons malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT gehrigandrea malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT sutterchristian malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT engelchristoph malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT niederacherdieter malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT steinemanndoris malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT hahneneric malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT kastkarin malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT arnoldnorbert malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT varonmateevaraymonda malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT wanddorothea malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT godwinandrewk malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT evansdgareth malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT frostdebra malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT perkinsjo malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT adlardjulian malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT izattlouise malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT platteradka malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT eelesros malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT ellissteve malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT hamannute malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT garberjudy malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT fostiraflorentia malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT fountzilasgeorge malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT pasinibarbara malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT gianninigiuseppe malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT rizzolopiera malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT russoantonio malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT cortesilaura malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT papilaura malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT varescoliliana malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT pallidomenico malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT zannaines malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT savareseantonella malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT radicepaolo malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT manoukiansiranoush malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT peisselbernard malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT barilemonica malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT bonannibernardo malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT vielalessandra malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT pensottivaleria malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT tommasistefania malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT peterlongopaolo malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT weitzeljeffreyn malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT osorioana malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT benitezjavier malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT mcguffoglesley malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT healeysue malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT gerdesannemarie malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT ejlertsenbent malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT hansenthomasvo malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT steelelinda malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT dingyuanchun malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT tungnadine malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT janaviciusramunas malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT goldgardavide malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT buyssaundras malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT dalymaryb malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT baneanita malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT terrymarybeth malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT johnestherm malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT southeymelissa malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT eastondouglasf malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT chenevixtrenchgeorgia malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT antoniouantonisc malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12
AT ottinilaura malebreastcancerinbrca1andbrca2mutationcarrierspathologydatafromtheconsortiumofinvestigatorsofmodifiersofbrca12