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Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

BACKGROUND: Alzheimer disease (AD) and other tauopathies develop cerebral intracellular inclusions of hyperphosphorylated tau. Epidemiological and experimental evidence suggests a clear link between type 2 diabetes mellitus and AD. In AD animal models, tau pathology is exacerbated by metabolic comor...

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Detalles Bibliográficos
Autores principales:	Barini, Erica, Antico, Odetta, Zhao, Yingjun, Asta, Francesco, Tucci, Valter, Catelani, Tiziano, Marotta, Roberto, Xu, Huaxi, Gasparini, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746897/ https://www.ncbi.nlm.nih.gov/pubmed/26858121 http://dx.doi.org/10.1186/s13024-016-0082-7

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