A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation

We previously described diaryl trifluorothiazoline compound 1a (hereafter referred to as fluorizoline) as a first-in-class small molecule that induces p53-independent apoptosis in a wide range of tumor cell lines. Fluorizoline directly binds to prohibitin 1 and 2 (PHBs), two proteins involved in the...

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Detalles Bibliográficos
Autores principales: Moncunill-Massaguer, Cristina, Saura-Esteller, José, Pérez-Perarnau, Alba, Palmeri, Claudia Mariela, Núñez-Vázquez, Sonia, Cosialls, Ana M., González-Gironès, Diana M., Pomares, Helena, Korwitz, Anne, Preciado, Sara, Albericio, Fernando, Lavilla, Rodolfo, Pons, Gabriel, Langer, Thomas, Iglesias-Serret, Daniel, Gil, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747186/
https://www.ncbi.nlm.nih.gov/pubmed/26497683

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