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Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model

Colon cancer liver metastasis is often the lethal aspect of this disease. Well-isolated metastases are candidates for surgical resection, but recurrence is common. Better adjuvant treatment is therefore needed to reduce or prevent recurrence. In the present study, HT-29 human colon cancer cells expr...

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Autores principales: Murakami, Takashi, Hiroshima, Yukihiko, Zhao, Ming, Zhang, Yong, Chishima, Takashi, Tanaka, Kuniya, Bouvet, Michael, Endo, Itaru, Hoffman, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747193/
https://www.ncbi.nlm.nih.gov/pubmed/26497690
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author Murakami, Takashi
Hiroshima, Yukihiko
Zhao, Ming
Zhang, Yong
Chishima, Takashi
Tanaka, Kuniya
Bouvet, Michael
Endo, Itaru
Hoffman, Robert M.
author_facet Murakami, Takashi
Hiroshima, Yukihiko
Zhao, Ming
Zhang, Yong
Chishima, Takashi
Tanaka, Kuniya
Bouvet, Michael
Endo, Itaru
Hoffman, Robert M.
author_sort Murakami, Takashi
collection PubMed
description Colon cancer liver metastasis is often the lethal aspect of this disease. Well-isolated metastases are candidates for surgical resection, but recurrence is common. Better adjuvant treatment is therefore needed to reduce or prevent recurrence. In the present study, HT-29 human colon cancer cells expressing red fluorescent protein (RFP) were used to establish liver metastases in nude mice. Mice with a single liver metastasis were randomized into bright-light surgery (BLS) or the combination of BLS and adjuvant treatment with tumor-targeting S. typhimurium A1-R. Residual tumor fluorescence after BLS was clearly visualized at high magnification by fluorescence imaging. Adjuvant treatment with S. typhimurium A1-R was highly effective to increase survival and disease-free survival after BLS of liver metastasis. The results suggest the future clinical potential of adjuvant S. typhimurium A1-R treatment after liver metastasis resection.
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spelling pubmed-47471932016-03-25 Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model Murakami, Takashi Hiroshima, Yukihiko Zhao, Ming Zhang, Yong Chishima, Takashi Tanaka, Kuniya Bouvet, Michael Endo, Itaru Hoffman, Robert M. Oncotarget Research Paper Colon cancer liver metastasis is often the lethal aspect of this disease. Well-isolated metastases are candidates for surgical resection, but recurrence is common. Better adjuvant treatment is therefore needed to reduce or prevent recurrence. In the present study, HT-29 human colon cancer cells expressing red fluorescent protein (RFP) were used to establish liver metastases in nude mice. Mice with a single liver metastasis were randomized into bright-light surgery (BLS) or the combination of BLS and adjuvant treatment with tumor-targeting S. typhimurium A1-R. Residual tumor fluorescence after BLS was clearly visualized at high magnification by fluorescence imaging. Adjuvant treatment with S. typhimurium A1-R was highly effective to increase survival and disease-free survival after BLS of liver metastasis. The results suggest the future clinical potential of adjuvant S. typhimurium A1-R treatment after liver metastasis resection. Impact Journals LLC 2015-10-19 /pmc/articles/PMC4747193/ /pubmed/26497690 Text en Copyright: © 2015 Murakami et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Murakami, Takashi
Hiroshima, Yukihiko
Zhao, Ming
Zhang, Yong
Chishima, Takashi
Tanaka, Kuniya
Bouvet, Michael
Endo, Itaru
Hoffman, Robert M.
Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model
title Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model
title_full Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model
title_fullStr Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model
title_full_unstemmed Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model
title_short Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model
title_sort adjuvant treatment with tumor-targeting salmonella typhimurium a1-r reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747193/
https://www.ncbi.nlm.nih.gov/pubmed/26497690
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