Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E

Cancer-testis antigen MAGE-C2 is normally expressed in testis but aberrantly expressed in various kinds of tumors. Its functions in tumor cells are mostly unknown. Here, we show that MAGE-C2 binds directly to the RING domain protein Rbx1, and participates in Skp1-Cullin1-F box protein (SCF) complex....

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Detalles Bibliográficos
Autores principales: Hao, Jiaqing, Song, Xiao, Wang, Jingjing, Guo, Chengli, Li, Yan, Li, Bing, Zhang, Yu, Yin, Yanhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747207/
https://www.ncbi.nlm.nih.gov/pubmed/26540345

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