Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia

Increased expression of c-MYC is observed in both Acute Myeloid Leukemia (AML) and T- cell Acute Lymphoblastic Leukemia (T-ALL). MYC binding protein 2 (MYCBP2) is a probable E3 ubiquitin ligase and its function in leukemia is unknown. IKZF1 deletion is associated with the development and poor outcom...

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Detalles Bibliográficos
Autores principales: Ge, Zheng, Guo, Xing, Li, Jianyong, Hartman, Melanie, Kawasawa, Yuka Imamura, Dovat, Sinisa, Song, Chunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747226/
https://www.ncbi.nlm.nih.gov/pubmed/26517351

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