Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5

Recent studies have shown that fusarochromanone (FC101), a mycotoxin, is cytotoxic in a variety of cell lines. However, the molecular mechanism underlying its cytotoxicity remains elusive. Here we found that FC101 induced cell death in COS7 and HEK293 cells in part by activating JNK pathway. This is...

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Detalles Bibliográficos
Autores principales: Gu, Ying, Barzegar, Mansoureh, Chen, Xin, Wu, Yang, Shang, Chaowei, Mahdavian, Elahe, Salvatore, Brian A., Jiang, Shanxiang, Huang, Shile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747228/
https://www.ncbi.nlm.nih.gov/pubmed/26517353

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