Mutational profiling of colorectal cancers with microsatellite instability

Microsatellite instability (MSI) is caused by defective mismatch repair in 15–20% of colorectal cancers (CRCs). Higher mutation loads in tumors with mismatch repair deficiency can predict response to pembrolizumab, an anti-programmed death 1 (PD-1) immune checkpoint inhibitor. We analyzed the mutati...

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Detalles Bibliográficos
Autores principales: Lin, Elaine I., Tseng, Li-Hui, Gocke, Christopher D., Reil, Stacy, Le, Dung T., Azad, Nilofer S., Eshleman, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747229/
https://www.ncbi.nlm.nih.gov/pubmed/26517354

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