A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects

Rho family GTPases act as molecular switches regulating actin cytoskeleton dynamics. Attenuation of their signaling capacity is provided by GTPase-activating proteins (GAPs), including p190A, that promote the intrinsic GTPase activity of Rho proteins. In the current study we have performed a small-s...

Descripción completa

Detalles Bibliográficos
Autores principales: Stewart, Katherine, Gaitan, Yaned, Shafer, Maxwell E. R., Aoudjit, Lamine, Hu, Di, Sharma, Richa, Tremblay, Mathieu, Ishii, Hidetaka, Marcotte, Michael, Stanga, Daniela, Tang, You Chi, Boualia, Sami Kamel, Nguyen, Alana H. T., Takano, Tomoko, Lamarche-Vane, Nathalie, Vidal, Silvia, Bouchard, Maxime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747337/
https://www.ncbi.nlm.nih.gov/pubmed/26859289
http://dx.doi.org/10.1371/journal.pgen.1005785

Ejemplares similares

Ejemplares similares