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Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma
Despite the substantial data supporting the oncogenic role of Ack1, the predictive value and biologic role of Ack1 in hepatocellular carcinoma (HCC) metastasis remains unknown. In this study, both correlations of Ack1 expression with prognosis of HCC, and the role of Ack1 in metastasis of HCC were i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747357/ https://www.ncbi.nlm.nih.gov/pubmed/26536663 |
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author | Lei, Xiong Li, Yun-feng Chen, Guo-dong Ou, Di-peng Qiu, Xiao-xin Zuo, Chao-hui Yang, Lian-Yue |
author_facet | Lei, Xiong Li, Yun-feng Chen, Guo-dong Ou, Di-peng Qiu, Xiao-xin Zuo, Chao-hui Yang, Lian-Yue |
author_sort | Lei, Xiong |
collection | PubMed |
description | Despite the substantial data supporting the oncogenic role of Ack1, the predictive value and biologic role of Ack1 in hepatocellular carcinoma (HCC) metastasis remains unknown. In this study, both correlations of Ack1 expression with prognosis of HCC, and the role of Ack1 in metastasis of HCC were investigated in vitro and in vivo. Our results showed that Ack1 was overexpressed in human HCC tissues and cell lines. High Ack1 expression was associated with HCC metastasis and determined as a significant and independent prognostic factor for HCC after liver resection. Ack1 promoted HCC invasion and metastasis in vitro and in vivo. Mechanistically, we confirmed that Ack1 enhanced invasion and metastasis of HCC via EMT by mediating AKT phosphorylation. In conclusion, our study shows Ack1 is a novel prognostic biomarker for HCC and promotes metastasis of HCC via EMT by activating AKT signaling. |
format | Online Article Text |
id | pubmed-4747357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-47473572016-03-24 Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma Lei, Xiong Li, Yun-feng Chen, Guo-dong Ou, Di-peng Qiu, Xiao-xin Zuo, Chao-hui Yang, Lian-Yue Oncotarget Research Paper Despite the substantial data supporting the oncogenic role of Ack1, the predictive value and biologic role of Ack1 in hepatocellular carcinoma (HCC) metastasis remains unknown. In this study, both correlations of Ack1 expression with prognosis of HCC, and the role of Ack1 in metastasis of HCC were investigated in vitro and in vivo. Our results showed that Ack1 was overexpressed in human HCC tissues and cell lines. High Ack1 expression was associated with HCC metastasis and determined as a significant and independent prognostic factor for HCC after liver resection. Ack1 promoted HCC invasion and metastasis in vitro and in vivo. Mechanistically, we confirmed that Ack1 enhanced invasion and metastasis of HCC via EMT by mediating AKT phosphorylation. In conclusion, our study shows Ack1 is a novel prognostic biomarker for HCC and promotes metastasis of HCC via EMT by activating AKT signaling. Impact Journals LLC 2015-10-20 /pmc/articles/PMC4747357/ /pubmed/26536663 Text en Copyright: © 2015 Lei et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Lei, Xiong Li, Yun-feng Chen, Guo-dong Ou, Di-peng Qiu, Xiao-xin Zuo, Chao-hui Yang, Lian-Yue Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma |
title | Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma |
title_full | Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma |
title_fullStr | Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma |
title_full_unstemmed | Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma |
title_short | Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma |
title_sort | ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747357/ https://www.ncbi.nlm.nih.gov/pubmed/26536663 |
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