Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2

Deamidation of glutamine to glutamate by glutaminase 1 (GLS1, also called GLS) and GLS2 is an essential step in both glutaminolysis and glutathione (GSH) biosynthesis. However, mechanisms whereby cancer cells regulate glutamine catabolism remains largely unknown. We report here that N-Myc, an essent...

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Detalles Bibliográficos
Autores principales: Xiao, Daibiao, Ren, Ping, Su, Hexiu, Yue, Ming, Xiu, Ruijuan, Hu, Yufeng, Liu, Hudan, Qing, Guoliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747359/
https://www.ncbi.nlm.nih.gov/pubmed/26528759

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