Epigenetic downregulation of the ISG15–conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma

We identified the UBE2L6 gene, encoding the ISG15-conjugating enzyme UbcH8, as one gene significantly downregulated by promoter hypermethylation in nasopharyngeal carcinoma (NPC). Reduced expression of the UbcH8 protein correlated with poor outcome in NPC patients. Restored expression of UBE2L6 supp...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaoying, Wei, Jiazhang, Chen, Fu, Xiao, Xue, Huang, Tingting, He, Qian, Wang, Shumin, Du, Chunping, Mo, Yingxi, Lin, Longde, Xie, Ying, Wei, Lili, Lan, Ying, Murata, Mairiko, Huang, Guangwu, Ernberg, Ingemar, Matskova, Liudmila, Zhang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747391/
https://www.ncbi.nlm.nih.gov/pubmed/26506425

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