E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling

Inhibition of Poly(ADP-ribose) Polymerase1 (PARP1) impairs DNA damage repair, and early generation PARP1/2 inhibitors (olaparib, niraparib, etc.) have demonstrated clinical proof of concept for cancer treatment. Here, we describe the development of the novel PARP inhibitor E7449, a potent PARP1/2 in...

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Detalles Bibliográficos
Autores principales: McGonigle, Sharon, Chen, Zhihong, Wu, Jiayi, Chang, Paul, Kolber-Simonds, Donna, Ackermann, Karen, Twine, Natalie C., Shie, Jue-Lon, Miu, Jingzang Tao, Huang, Kuan-Chun, Moniz, George A., Nomoto, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747407/
https://www.ncbi.nlm.nih.gov/pubmed/26513298

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