Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-β-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts

Transforming growth factor-β (TGF-β) is central during the pathogenesis of pulmonary fibrosis, in which the plasminogen activator inhibitor-1 (PAI-1) also has an established role. TGF-β is also known to be the strongest inducer of PAI-1. To investigate the link between PAI-1 and TGF-β in fibrotic pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Omori, Keitaro, Hattori, Noboru, Senoo, Tadashi, Takayama, Yusuke, Masuda, Takeshi, Nakashima, Taku, Iwamoto, Hiroshi, Fujitaka, Kazunori, Hamada, Hironobu, Kohno, Nobuoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747467/
https://www.ncbi.nlm.nih.gov/pubmed/26859294
http://dx.doi.org/10.1371/journal.pone.0148969

Ejemplares similares

Ejemplares similares