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Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study

BACKGROUND: Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) partici...

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Autores principales: Zheng, Danni, Arima, Hisatomi, Sato, Shoichiro, Gasparrini, Antonio, Heeley, Emma, Delcourt, Candice, Lo, Serigne, Huang, Yining, Wang, Jiguang, Stapf, Christian, Robinson, Thompson, Lavados, Pablo, Chalmers, John, Anderson, Craig S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747478/
https://www.ncbi.nlm.nih.gov/pubmed/26859491
http://dx.doi.org/10.1371/journal.pone.0149040
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author Zheng, Danni
Arima, Hisatomi
Sato, Shoichiro
Gasparrini, Antonio
Heeley, Emma
Delcourt, Candice
Lo, Serigne
Huang, Yining
Wang, Jiguang
Stapf, Christian
Robinson, Thompson
Lavados, Pablo
Chalmers, John
Anderson, Craig S.
author_facet Zheng, Danni
Arima, Hisatomi
Sato, Shoichiro
Gasparrini, Antonio
Heeley, Emma
Delcourt, Candice
Lo, Serigne
Huang, Yining
Wang, Jiguang
Stapf, Christian
Robinson, Thompson
Lavados, Pablo
Chalmers, John
Anderson, Craig S.
author_sort Zheng, Danni
collection PubMed
description BACKGROUND: Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale. METHODS: INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150–220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI. RESULTS: Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99–1.91) for 10°C, 1.92 (1.31–2.81) for 0°C, 3.13 (1.89–5.19) for -10°C, and 5.76 (2.30–14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses. CONCLUSIONS: Exposure to low ambient temperature within several hours increases the risk of ICH. TRIAL REGISTRATION: ClinicalTrials.gov NCT00716079
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spelling pubmed-47474782016-02-22 Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study Zheng, Danni Arima, Hisatomi Sato, Shoichiro Gasparrini, Antonio Heeley, Emma Delcourt, Candice Lo, Serigne Huang, Yining Wang, Jiguang Stapf, Christian Robinson, Thompson Lavados, Pablo Chalmers, John Anderson, Craig S. PLoS One Research Article BACKGROUND: Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale. METHODS: INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150–220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI. RESULTS: Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99–1.91) for 10°C, 1.92 (1.31–2.81) for 0°C, 3.13 (1.89–5.19) for -10°C, and 5.76 (2.30–14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses. CONCLUSIONS: Exposure to low ambient temperature within several hours increases the risk of ICH. TRIAL REGISTRATION: ClinicalTrials.gov NCT00716079 Public Library of Science 2016-02-09 /pmc/articles/PMC4747478/ /pubmed/26859491 http://dx.doi.org/10.1371/journal.pone.0149040 Text en © 2016 Zheng et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zheng, Danni
Arima, Hisatomi
Sato, Shoichiro
Gasparrini, Antonio
Heeley, Emma
Delcourt, Candice
Lo, Serigne
Huang, Yining
Wang, Jiguang
Stapf, Christian
Robinson, Thompson
Lavados, Pablo
Chalmers, John
Anderson, Craig S.
Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
title Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
title_full Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
title_fullStr Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
title_full_unstemmed Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
title_short Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
title_sort low ambient temperature and intracerebral hemorrhage: the interact2 study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747478/
https://www.ncbi.nlm.nih.gov/pubmed/26859491
http://dx.doi.org/10.1371/journal.pone.0149040
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