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Mechanical Stretch Inhibits MicroRNA499 via p53 to Regulate Calcineurin-A Expression in Rat Cardiomyocytes

BACKGROUND: MicroRNAs play an important role in cardiac remodeling. MicroRNA 499 (miR499) is highly enriched in cardiomyocytes and targets the gene for Calcineurin A (CnA), which is associated with mitochondrial fission and apoptosis. The mechanism regulating miR499 in stretched cardiomyocytes and i...

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Detalles Bibliográficos
Autores principales:	Chua, Su-Kiat, Wang, Bao-Wei, Lien, Li-Ming, Lo, Huey-Ming, Chiu, Chiung-Zuan, Shyu, Kou-Gi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747570/ https://www.ncbi.nlm.nih.gov/pubmed/26859150 http://dx.doi.org/10.1371/journal.pone.0148683

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