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Sequestration and Red Cell Deformability as Determinants of Hyperlactatemia in Falciparum Malaria
Background. Hyperlactatemia is a strong predictor of mortality in severe falciparum malaria. Sequestered parasitized erythrocytes and reduced uninfected red blood cell deformability (RCD) compromise microcirculatory flow, leading to anaerobic glycolysis. Methods. In a cohort of patients with falcipa...
Autores principales: | Ishioka, Haruhiko, Ghose, Aniruddha, Charunwatthana, Prakaykaew, Maude, Richard, Plewes, Katherine, Kingston, Hugh, Intharabut, Benjamas, Woodrow, Charlie, Chotivanich, Kesinee, Sayeed, Abdullah Abu, Hasan, Mahtab Uddin, Day, Nicholas P., Faiz, Abul, White, Nicholas J., Hossain, Amir, Dondorp, Arjen M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747623/ https://www.ncbi.nlm.nih.gov/pubmed/26494775 http://dx.doi.org/10.1093/infdis/jiv502 |
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