Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes

Detection of somatic mutations in HLA genes using whole-exome sequencing (WES) is hampered by the high polymorphism of the HLA loci, which prevents alignment of sequencing reads to the human reference genome. We describe a computational pipeline that enables accurate inference of germline alleles of...

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Detalles Bibliográficos
Autores principales: Shukla, Sachet A., Rooney, Michael S., Rajasagi, Mohini, Tiao, Grace, Dixon, Philip M., Lawrence, Michael S., Stevens, Jonathan, Lane, William J., Dellagatta, Jamie L., Steelman, Scott, Sougnez, Carrie, Cibulskis, Kristian, Kiezun, Adam, Brusic, Vladimir, Wu, Catherine J., Getz, Gad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747795/
https://www.ncbi.nlm.nih.gov/pubmed/26372948
http://dx.doi.org/10.1038/nbt.3344

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