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Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism

The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colore...

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Detalles Bibliográficos
Autores principales:	Wohak, Laura E., Krais, Annette M., Kucab, Jill E., Stertmann, Julia, Øvrebø, Steinar, Seidel, Albrecht, Phillips, David H., Arlt, Volker M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2014
Materias:	Toxicokinetics and Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748000/ https://www.ncbi.nlm.nih.gov/pubmed/25398514 http://dx.doi.org/10.1007/s00204-014-1409-1

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