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KRAS insertion mutations are oncogenic and exhibit distinct functional properties
Oncogenic KRAS mutations introduce discrete amino acid substitutions that reduce intrinsic Ras GTPase activity and confer resistance to GTPase-activating proteins (GAPs). Here we discover a partial duplication of the switch 2 domain of K-Ras encoding a tandem repeat of amino acids G60_A66dup in a ch...
Autores principales: | White, Yasmine, Bagchi, Aditi, Van Ziffle, Jessica, Inguva, Anagha, Bollag, Gideon, Zhang, Chao, Carias, Heidi, Dickens, David, Loh, Mignon, Shannon, Kevin, Firestone, Ari J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748120/ https://www.ncbi.nlm.nih.gov/pubmed/26854029 http://dx.doi.org/10.1038/ncomms10647 |
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