Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer

The mechanisms of metastatic progression from hormonal therapy (HT) are largely unknown in luminal breast cancer. Here we demonstrate the enrichment of CD133(hi)/ER(lo) cancer cells in clinical specimens following neoadjuvant endocrine therapy and in HT refractory metastatic disease. We develop expe...

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Detalles Bibliográficos
Autores principales: Sansone, Pasquale, Ceccarelli, Claudio, Berishaj, Marjan, Chang, Qing, Rajasekhar, Vinagolu K., Perna, Fabiana, Bowman, Robert L., Vidone, Michele, Daly, Laura, Nnoli, Jennifer, Santini, Donatella, Taffurelli, Mario, Shih, Natalie N. C., Feldman, Michael, Mao, Jun J., Colameco , Christopher, Chen, Jinbo, DeMichele, Angela, Fabbri, Nicola, Healey, John H., Cricca, Monica, Gasparre, Giuseppe, Lyden, David, Bonafé, Massimiliano, Bromberg, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748123/
https://www.ncbi.nlm.nih.gov/pubmed/26858125
http://dx.doi.org/10.1038/ncomms10442

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