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The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency

4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The chemical is converted into 4-hydroxyaminoquinoline 1-oxide and gives rise to three main DNA adducts, N-(deoxyguanosin-8-yl)-4AQO, 3-(desoxyguan...

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Detalles Bibliográficos
Autores principales:	Brüsehafer, Katja, Manshian, Bella B., Doherty, Ann T., Zaïr, Zoulikha M., Johnson, George E., Doak, Shareen H., Jenkins, Gareth J. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Original Manuscript
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748179/ https://www.ncbi.nlm.nih.gov/pubmed/26362870 http://dx.doi.org/10.1093/mutage/gev069

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